Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil
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Data
2015
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Resumo
The aim of the present study was to assess the prevalence of Haemophilus influenzae type b (Hib) nasopharyngeal
(NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely
administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who
had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains
were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the
12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified
in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and
48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly
more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The
overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was
detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low
after 10 years of the introduction of the Hib vaccine.
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Brazil, Haemophilus influenzae type b, Nasopharyngeal carriage, Hib conjugate vaccine
Citação
ZANELLA, Rosemeire Cobo et al. Evaluation of Haemophilus influenzae type b carrier status among children 10 years after the introduction of Hib vaccine in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 6, p. 755-759, 2015.