Incidência de arritmias ventriculares após terapia celular em pacientes com cardiomiopatia chagásica
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Data
2014
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Background: Treatment with stem cells in several cardiomyopathies may be related to the increase in arrhythmias.
Objectives: To determine whether intracoronary injection of stem cells in patients with Chagas cardiomyopathy is associated with increased
incidence of ventricular arrhythmias, compared to the Control Group.
Methods: A retrospective cohort study that evaluated the medical records of 60 patients who participated in a previous cross-sectional study.
The following data were collected: age, gender, drugs used and Holter variables that demonstrated the presence of arrhythmias. Holter was
performed in four stages: randomization, 2, 6 and 12 months segments. The Control Group received medical treatment and intracoronary
injection of placebo and the Study Group had drug treatment and autologous stem cell implant.
Results: There was no difference between Control Group and Study Group when analyzing the arrhythmia criteria. In the intra-group analysis,
significant difference was found between the Holter tests of the Study Group for the variable total ventricular premature beats when compared
with baseline, with p = 0.014 between Holter at randomization and Holter at 2 months, p = 0.004 between Holter at randomization
and Holter at 6 months, and p = 0.014 between Holter at randomization and Holter at 12 months. The variable non-sustained ventricular
tachycardia between Holter at randomization and Holter at 6 months showed p = 0.036.
Conclusion: The intracoronary injection of stem cells did not increase the incidence of ventricular arrhythmias in patients with Chagas
cardiomyopathy compared to the Control Group.
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Arritmias cardíacas, Cardiomiopatia chagásica, Transplante de células-tronco, Arrhythmias, Cardiac, Chagas cardiomyopathy, Stem cell transplantation
Citação
BARROSO, Adriana Sebba Barroso de et al. Incidência de arritmias ventriculares após terapia celular em pacientes com cardiomiopatia chagásica. Arquivos Brasileiros de Cardiologia, Rio de Janeiro, v. 102, n. 5, p. 489-494, 2014.