Do COPD and healthy subjects have similar acute inflammatory response induced by sub-maximum effort test?
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2017
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Introduction: COPD (chronic obstructive pulmonary disease) presents a low degree of systemic inflammation
responsible for the disease’s extra pulmonary consequences. Its inflammatory profile can be altered by acute
exercise. However, acute effects of a sub maximum test, capable of reproducing activities of daily living (ADL) in
sedentary COPD individuals, are not well-known
Objective: To evaluate if the six-minute walk test (6MWT) is capable of altering interleukin-6 (IL-6) blood levels,
tumoral necrosis factor alfa (TNF-α) and hypersensitive C reactive protein (hs-CRP) in relation to the basal level of
COPD individuals.
Methods: 21 individuals with moderate and severe COPD and 8 healthy individuals, with no history of smoking,
sedentary, matched by age were assessed regarding plasma levels of IL-6, TNF-α and hs-CRP before and right
after a 6MWT. They also did spirometry and body composition analysis.
Results: 6MWT did not provoke significant alteration in IL-6 levels in COPD individuals (pre=4.53 ± 9.0 pg/ml vs.
post=7.14 ± 11.31 pg/ml, p=0.11), whereas in healthy individuals this increase was significant (pre=1.56 ± 6.45 pg/ml
vs. post=4.37 ± 8.0 pg/ml, p<0.01). COPD individuals present higher hs-CRP blood levels when compared to
healthy subjects both in rest (8.15 ± 9.68 pg/ml vs. 2.60 ± 1.88 pg/ml, p=0.02), and after exercise (8.18 ± 9.08 pg/ml
vs. 2.62 ± 1.85 pg/ml, p=0.02. TNF-α did not present difference between groups during rest (COPD=2.13 ± 1.03
pg/ml vs. healthy=2.00 ± 0.59 pg/ml, p>0.05) as well as after 6MWT (COPD=2.48 ± 1.92 pg/ml vs. healthy=1.89 ±
0.69 pg/ml, p>0.05), and their intragroup focus was not affected by the effort (p>0.05).
Conclusions: In COPD patients, 6MWT does not induce acute inflammatory response of IL-6 at the same
proportion of that of healthy subjects. Hs-CRP’s and TNFα’s response to 6MWT was similar between groups. COPD
patients presented higher concentrations of hs-CRP than healthy individuals.
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Chronic obstructive pulmonary disease, Exercise, Inflammation
Citação
CORRÊA, Krislainy de Sousa. Do COPD and healthy subjects have similar acute inflammatory response induced by sub-maximum effort test? Journal of Physiotherapy & Physical Rehabilitation, Brussels , v. 2, n. 1, p. 1000123, 2017. DOI: 10.4172/2573-0312.1000123. Disponível em: https://www.hilarispublisher.com/archive/jppr-volume-2-issue-1-year-2017.html. Acesso em: 22 ago. 2024.