Do COPD and healthy subjects have similar acute inflammatory response induced by sub-maximum effort test?

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dc.creatorCorrêa, Krislainy de Sousa
dc.creatorCosta, Adeliane Castro da
dc.creatorCarvalho, Ana Paula Perillo Ferreira
dc.creatorSilva Júnior, José Laerte Rodrigues da
dc.creatorMoraes, Maria Rosedália de
dc.creatorKipnis, Ana Paula Junqueira
dc.creatorRabahi, Marcelo Fouad
dc.date.accessioned2024-10-17T14:55:16Z
dc.date.available2024-10-17T14:55:16Z
dc.date.issued2017
dc.description.abstractIntroduction: COPD (chronic obstructive pulmonary disease) presents a low degree of systemic inflammation responsible for the disease’s extra pulmonary consequences. Its inflammatory profile can be altered by acute exercise. However, acute effects of a sub maximum test, capable of reproducing activities of daily living (ADL) in sedentary COPD individuals, are not well-known Objective: To evaluate if the six-minute walk test (6MWT) is capable of altering interleukin-6 (IL-6) blood levels, tumoral necrosis factor alfa (TNF-α) and hypersensitive C reactive protein (hs-CRP) in relation to the basal level of COPD individuals. Methods: 21 individuals with moderate and severe COPD and 8 healthy individuals, with no history of smoking, sedentary, matched by age were assessed regarding plasma levels of IL-6, TNF-α and hs-CRP before and right after a 6MWT. They also did spirometry and body composition analysis. Results: 6MWT did not provoke significant alteration in IL-6 levels in COPD individuals (pre=4.53 ± 9.0 pg/ml vs. post=7.14 ± 11.31 pg/ml, p=0.11), whereas in healthy individuals this increase was significant (pre=1.56 ± 6.45 pg/ml vs. post=4.37 ± 8.0 pg/ml, p<0.01). COPD individuals present higher hs-CRP blood levels when compared to healthy subjects both in rest (8.15 ± 9.68 pg/ml vs. 2.60 ± 1.88 pg/ml, p=0.02), and after exercise (8.18 ± 9.08 pg/ml vs. 2.62 ± 1.85 pg/ml, p=0.02. TNF-α did not present difference between groups during rest (COPD=2.13 ± 1.03 pg/ml vs. healthy=2.00 ± 0.59 pg/ml, p>0.05) as well as after 6MWT (COPD=2.48 ± 1.92 pg/ml vs. healthy=1.89 ± 0.69 pg/ml, p>0.05), and their intragroup focus was not affected by the effort (p>0.05). Conclusions: In COPD patients, 6MWT does not induce acute inflammatory response of IL-6 at the same proportion of that of healthy subjects. Hs-CRP’s and TNFα’s response to 6MWT was similar between groups. COPD patients presented higher concentrations of hs-CRP than healthy individuals.
dc.identifier.citationCORRÊA, Krislainy de Sousa. Do COPD and healthy subjects have similar acute inflammatory response induced by sub-maximum effort test? Journal of Physiotherapy & Physical Rehabilitation, Brussels , v. 2, n. 1, p. 1000123, 2017. DOI: 10.4172/2573-0312.1000123. Disponível em: https://www.hilarispublisher.com/archive/jppr-volume-2-issue-1-year-2017.html. Acesso em: 22 ago. 2024.
dc.identifier.doi10.4172/2573-0312.1000123
dc.identifier.issne- 2573-0312
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25601
dc.language.isoeng
dc.publisher.countryBelgica
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectChronic obstructive pulmonary disease
dc.subjectExercise
dc.subjectInflammation
dc.titleDo COPD and healthy subjects have similar acute inflammatory response induced by sub-maximum effort test?
dc.typeArtigo

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