Hepatitis B virus infection among oncohematologic disease patients in central Brazil: prevalence, risk factors and immunization
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Data
2019
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Introduction: Carriers of oncohematological diseases are at high risk for hepatitis B virus
(HBV) infection.
Objective and method: To investigate the epidemiology of HBV infection in Goiânia, Central
Brazil, 322 individuals with oncohematological diseases (leukemias, Hodgkin lymphoma
and non-Hodgkin lymphoma) were interviewed and blood samples were collected for the
detection of serological markers of HBV-DNA by polymerase chain reaction (PCR). Medical
records of participants were also reviewed.
Results: Non-Hodgkin’s lymphomas (n = 99) and chronic myeloid leukemia (n = 108) were
the most frequent oncohematological diseases. The overall prevalence of HBV was 13.97%
(45/322). Of the total participants, 8.69% (28/322) presented isolated positivity for anti-HBs,
suggesting low vaccine coverage. HBV-DNA was detected in 25% (1/4) of HBsAg positive sam ples and in 25% (3/12) of anti-HBc isolated, suggesting HBV occultinfection. All samples were
identified as subgenotype A1. Entries in patient records and the findings of this investigation
suggest anti-HBc seroconversion during oncologic treatment. Age 50 years or over and use
of a central catheter during therapy were associated with HBV exposure.
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Epidemiology, Leukemia, Lymphoma, Hepatitis B, Oncology
Citação
PESSONI, Grécia C. et al. Hepatitis B virus infection among oncohematologic disease patients in central Brazil: prevalence, risk factors and immunization. Hematology, Transfusion and Cell Therapy, Rio de Janeiro, v. 41, n. 3, p. 199-204, 2019. DOI: 10.1016/j.htct.2018.11.008. Disponível em: https://www.sciencedirect.com/science/article/pii/S253113791930032X?via%3Dihub. Acesso em: 7 fev. 2025.