Antifungal resistance, metabolic routes as drug targets, and new antifungal agents: an overview about endemic dimorphic fungi

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dc.creatorRocha, Juliana Alves Parente
dc.creatorBailão, Alexandre Melo
dc.creatorAmaral, Andre Correa
dc.creatorTaborda, Carlos Pelleschi
dc.creatorPaccez, Juliano Domiraci
dc.creatorBorges, Clayton Luiz
dc.creatorPereira, Maristela
dc.date.accessioned2024-08-16T12:46:56Z
dc.date.available2024-08-16T12:46:56Z
dc.date.issued2017
dc.description.abstractDiseases caused by fungi can occur in healthy people, but immunocompromised patients are the major risk group for invasive fungal infections. Cases of fungal resistance and the difficulty of treatment make fungal infections a public health problem. This review explores mechanisms used by fungi to promote fungal resistance, such as the mutation or overexpression of drug targets, efflux and degradation systems, and pleiotropic drug responses. Alternative novel drug targets have been investigated; these include metabolic routes used by fungi during infection, such as trehalose and amino acid metabolism and mitochondrial proteins. An overview of new antifungal agents, including nanostructured antifungals, as well as of repositioning approaches is discussed. Studies focusing on the development of vaccines against antifungal diseases have increased in recent years, as these strategies can be applied in combination with antifungal therapy to prevent posttreatment sequelae. Studies focused on the development of a pan-fungal vaccine and antifungal drugs can improve the treatment of immunocompromised patients and reduce treatment costs.
dc.identifier.citationPARENTE-ROCHA, Juliana Alves et al. Antifungal resistance, metabolic routes as drug targets, and new antifungal agents: an overview about endemic dimorphic fungi. Mediators of Inflammation, New Jersey, v. 2017, e 9870679, 2017. DOI: 10.1155/2017/9870679. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485324/. Acesso em: 9 ago. 2024.
dc.identifier.doi10.1155/2017/9870679
dc.identifier.issn0962-9351
dc.identifier.issne- 1466-1861
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25296
dc.language.isoeng
dc.publisher.countryEstados unidos
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleAntifungal resistance, metabolic routes as drug targets, and new antifungal agents: an overview about endemic dimorphic fungi
dc.typeArtigo

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