Optical properties and antiangiogenic activity of a chalcone derivate

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dc.creatorPontes, Susy Ricardo Lemes
dc.creatorAdriano Junior, Luizmar
dc.creatorManoel, Diego da Silva
dc.creatorSousa, Maria Alice Montes de
dc.creatorFonseca Rodriguez, Ruben Dario
dc.creatorLima, Rosa Silva
dc.creatorNoda Pérez, Caridad
dc.creatorReis, Paulo Roberto de Melo
dc.creatorCardoso, Cléver Gomes
dc.creatorLacerda, Elisângela de Paula Silveira
dc.creatorSouza, Márcio Adriano Rodrigues
dc.creatorGonçalves, Pablo José
dc.creatorDe Boni, Leonardo
dc.creatorFonseca, Tertius Lima da
dc.date.accessioned2023-08-24T10:38:28Z
dc.date.available2023-08-24T10:38:28Z
dc.date.issued2018
dc.description.abstractChalcones and their derivatives exhibit numerous pharmacological activities such as antibacterial, antifungal, cytotoxic, antinociceptive and anti-inflammatory. Recently, they have been assessed aiming for novel application in nonlinear optics and in the treatment of immune diseases and cancers. In this study, we investigate the optical properties of synthetic chalcona 1E,4E-1-(4-chlorophenyl)-5-(2,6,6-trimethylcyclohexen-1-yl)penta-1,4-dien-3-one (CAB7β) and its antiangiogenic potential using the chorioallantoic membrane (CAM) with the S180 sarcoma cell line. Experimental and theoretical results show intense absorption in the UVA-UVC region, which is associated with a π → π* transition with intramolecular charge transfer from the trimethyl-cyclohexen-1-yl ring to the chlorophenyl ring. Quantum chemical calculations of the first hyperpolarizability, accounting for both solvent and frequency dispersion effects, are in very good concordance with hyper-Rayleigh scattering measurements. In addition, two-photon absorption allowed band centered at 650 nm was observed. Concerning antiangiogenic activity, CAB7β causes a significant reduction in the total number, junctions, length and caliber of blood vessels stimulated by S180 cells reducing the presence of blood vessels, inflammatory cells and others elements related to angiogenic process. It is found that CAB7β is a versatile compound and a promising candidate for linear and nonlinear optical applications, in therapy against sarcoma and phototherapy.pt_BR
dc.identifier.citationLEMES, Susy Ricardo et al. Optical properties and antiangiogenic activity of a chalcone derivate. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Amsterdam, v. 204, p. 685-695, 2018. DOI: 10.1016/j.saa.2018.06.099. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1386142518306413?via%3Dihub. Acesso em: 17 ago. 2023.pt_BR
dc.identifier.doi10.1016/j.saa.2018.06.099
dc.identifier.issn1386-1425
dc.identifier.issne- 1873-3557
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1386142518306413?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleOptical properties and antiangiogenic activity of a chalcone derivatept_BR
dc.typeArtigopt_BR

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