Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice
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Data
2012
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Resumo
Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as “sofre-do-rim-quem-quer”
and “araticum-seco”, is a shrub of the Annonaceae family that occurs in several regions of Brazil. In folk
medicine the infusion of its leaves and twigs is used to treat rheumatism and renal colic, whereas the seed
powder is mixed with water to treat pediculosis. Previous studies have described biological activities of this
plant with cytotoxic, antitumoral, trypanocidal, leishmanicidal, antiplasmodial and antiprotozoal effects.
In the present work, genotoxicity and cytotoxicity of Duguetia furfuracea lyophilized leaf extract were
evaluated using the prophage λ induction test (SOS-Inductest) and mouse bone marrow micronucleus test.
Our results showed that Duguetia furfuracea lyophilized leaf extract did not present an increase either in
the induction of prophage λ (P>0.05) using the SOS-inductest or in the micronucleated polychromatic
erythrocytes (P>0.05) using the micronucleus test, suggesting absence of genotoxicity in both tests. On the
other hand, a significant decrease in the number of bacteria, (P<0.05), as well as a significant decrease in the
polychromatic erythrocytes and normochromatic erythrocytes ratio, (P<0.05), were observed, showing the
cytotoxic action of Duguetia furfuracea lyophilized leaf extract. Thus, Duguetia furfuracea did not present
the genotoxic action, but showed a cytotoxic effect in both assays utilized in the present work.
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Cytotoxicity, SOS-iductest, Duguetia furfuracea, Micronucleus test, Genotoxicity
Citação
SILVA, Carolina R.; VIEIRA, Pabline M.; SANTOS, Suzana C.; LEE, Chen-Chen. Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 84, n. 1, p. 149-156, Jan./Mar.2012.