Trypanocidal action of (−)-elatol involves an oxidative stress triggered by Mitochondria dysfunction

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dc.creatorDesoti, Vânia Cristina
dc.creatorBidoia, Danielle Lazarin
dc.creatorSudatti, Daniela Bueno
dc.creatorPereira, Renato Crespo
dc.creatorAlonso, Antonio
dc.creatorNakamura, Tania Ueda
dc.creatorDias Filho, Benedito Prado
dc.creatorNakamura, Celso Vataru
dc.creatorSilva, Sueli de Oliveira
dc.date.accessioned2018-06-14T11:39:33Z
dc.date.available2018-06-14T11:39:33Z
dc.date.issued2012
dc.description.abstractNatural compounds have shown good potential for the discovery of new chemotherapeutics for the treatment of Chagas’ disease. Recently, our group reported the effective trypanocidal activity of (−)-elatol, extracted from the red macroalgae Laurencia dendroidea present in the Brazilian coast against Trypanosoma cruzi. However, the mechanism of action of this compound has remained unclear. There are only hypotheses concerning its action on mitochondrial function. Here, we further investigated the mechanisms of action of (−)-elatol on trypomastigotes of T. cruzi. For this, we evaluated some biochemical alterations in trypomastigotes treated with (−)-elatol. Our results show that (−)-elatol induced depolarization of the mitochondrial membrane, an increase in the formation of mitochondrial superoxide anion and loss of cell membrane and DNA integrity. Additionally, (−)-elatol induced formation of autophagic vacuoles and a decrease in cell volume. All together, these results suggest that the trypanocidal action of (−)-elatol involves multiple events and mitochondria might be the initial target organelle. Our hypothesis is that the mitochondrial dysfunction leads to an increase of ROS production through the electron transport chain, which affects cell membrane and DNA integrity leading to different types of parasite death.pt_BR
dc.identifier.citationDESOTI, Vânia Cristina; LAZARIN, Danielle Bidoia; SUDATTI, Daniela Bueno; PEREIRA, Renato Crespo; ALONSO, Antonio; NAKAMURA, Tania Ueda; DIAS FILHO, Benedito Prado; NAKAMURA, Celso Vataru; OLIVEIRA Silva, Sueli de. Trypanocidal action of (−)-elatol involves an oxidative stress triggered by Mitochondria dysfunction. Marine Drugs, Basel, v. 10, p. 1631-1646, 2012.pt_BR
dc.identifier.doi10.3390/md10081631
dc.identifier.issne- 1660-3397
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15255
dc.language.isoengpt_BR
dc.publisher.countrySuicapt_BR
dc.publisher.departmentInstituto de Física - IF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subject(−)-elatolpt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectChagas diseasept_BR
dc.subjectMitochondriapt_BR
dc.subjectOxidative stresspt_BR
dc.titleTrypanocidal action of (−)-elatol involves an oxidative stress triggered by Mitochondria dysfunctionpt_BR
dc.typeArtigopt_BR

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