O papel da microbiota intestinal na síndrome do intestino irritável

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Data

2024-11-28

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Universidade Federal de Goiás

Resumo

Irritable Bowel Syndrome (IBS) is a common gastrointestinal condition characterized by abdominal pain, discomfort, distension, and changes in bowel habits, without detectable structural abnormalities. Recently, research on the gut microbiota has revealed a significant link between changes in the microbial composition of the intestine and the pathophysiology of IBS. This study, based on a literature review, reviewed the relationship between the gut microbiotaand IBS, analyzing articles from 2014 to 2024. Using the descriptors in Portuguese and their corresponding in English: “Síndrome do Irritável”, “Dysbiosis” and “Microbiota Intestinal”, this work reviewed the current evidence on the differences in the gut microbiota profile between patients with and without IBS, the verification of the efficacy of the most common treatments, and the possibility of using the microbiota profile as biomarkers for the diagnosis of the syndrome. The results suggest that patients with irritable bowel syndrome have a process of microbial dysbiosis that is both a cause and a consequence of IBS. Furthermore, therapeutic interventions focused on modulating the gut microbiota, such as the use of probiotics, antibiotics and dietary changes, have shown promise in the management of symptoms. The possibility of using the microbiota as a biomarker may bring a substantial advance in the diagnosis of IBS. This study highlights the importance of integrated approaches to understanding and treating IBS, suggesting that modulating the gut microbiota may be an effective therapeutic strategy.

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Palavras-chave

Microbiota intestinal, Síndrome do intestino irritável, Disbiose, Intestinal microbiota, Irritable bowelsyndrome, Dysbiosis

Citação

SIQUEIRA, Giovana Campos. O papel da microbiota intestinal na síndrome do intestino irritável. 2024. 103 f. Trabalho de Conclusão de Curso (Bacharelado em Biomedicina) - Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, 2024.