O papel da microbiota intestinal na síndrome do intestino irritável
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Data
2024-11-28
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Universidade Federal de Goiás
Resumo
Irritable Bowel Syndrome (IBS) is a common gastrointestinal condition
characterized by abdominal pain, discomfort, distension, and changes in bowel
habits, without detectable structural abnormalities. Recently, research on the
gut microbiota has revealed a significant link between changes in the microbial
composition of the intestine and the pathophysiology of IBS. This study, based
on a literature review, reviewed the relationship between the gut microbiotaand IBS, analyzing articles from 2014 to 2024. Using the descriptors in
Portuguese and their corresponding in English: “Síndrome do Irritável”,
“Dysbiosis” and “Microbiota Intestinal”, this work reviewed the current
evidence on the differences in the gut microbiota profile between patients with
and without IBS, the verification of the efficacy of the most common
treatments, and the possibility of using the microbiota profile as biomarkers
for the diagnosis of the syndrome. The results suggest that patients with
irritable bowel syndrome have a process of microbial dysbiosis that is both a
cause and a consequence of IBS. Furthermore, therapeutic interventions
focused on modulating the gut microbiota, such as the use of probiotics,
antibiotics and dietary changes, have shown promise in the management of
symptoms. The possibility of using the microbiota as a biomarker may bring a
substantial advance in the diagnosis of IBS. This study highlights the
importance of integrated approaches to understanding and treating IBS,
suggesting that modulating the gut microbiota may be an effective therapeutic
strategy.
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Palavras-chave
Microbiota intestinal, Síndrome do intestino irritável, Disbiose, Intestinal microbiota, Irritable bowelsyndrome, Dysbiosis
Citação
SIQUEIRA, Giovana Campos. O papel da microbiota intestinal na síndrome do intestino irritável. 2024. 103 f. Trabalho de Conclusão de Curso (Bacharelado em Biomedicina) - Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, 2024.