Atividade citotóxica e antiangiogênica de Punica granatum L., Punicaceae
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Data
2010
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activities in vitro and in vivo. In this work, the in vitro cytotoxicity was evaluated using the K-562
cell line and Ehrlich ascites tumour cells, by MTT tetrazolium reduction test and the trypan blue
exclusion test. In vivo studies investigated the increase in the survival time of Ehrlich tumour-bearing
mice after treatment with different doses of Punica granatum L. ethanol extract (12.5; 25; 50 e and
100 mg/kg), by gavages, for ten consecutive days. In addition, we also investigated the tumour
inhibition potential and antiangiogenic activity of this plant. In vitro results demonstrated a decrease
of K-562 and Ehrlich ascites tumour cells viability, with both methods used, in a dependent-manner
concentration. In vivo results showed a significant antitumor activity against Ehrlich ascites tumour
growth, increasing survival time. In parallel, we detected a significant inhibition of the tumour
growth, along with a decrease in the vascular pattern of the peritoneal wall. Thus, the data presented
herein clearly showed that Punica granatum L. has antitumor and antiangiogenic activities.
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Palavras-chave
Punica granatum, Tumor ascítico de Ehrlich, Punicaceae, Angiogênese, Atividade antitumoral, Citotoxicidade, Punica granatum L., Ehrlich ascites tumor, Punicaceae, Angiogenesis, Cytotoxicity
Citação
OLIVEIRA, Ligianne P. et al. Cytotoxic and antiangiogenic activities of Punica granatum L., Punicaceae. Revista Brasileira de Farmacognosia, Curitiba, v. 20, n. 2, p. 201-207, 2010.