Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus
| dc.creator | Oliveira, Ruberney da Silva de | |
| dc.creator | Biscaia, Stellee Marcela Petris | |
| dc.creator | Bellan, Daniel de Lima | |
| dc.creator | Viana, Sthefany Rodrigues Fernandes | |
| dc.creator | Leal, Maria Carolina Bezerra Di Medeiros | |
| dc.creator | Vasconcelos, Ana Flora Dalberto | |
| dc.creator | Liao, Luciano Morais | |
| dc.date.accessioned | 2024-03-07T13:33:38Z | |
| dc.date.available | 2024-03-07T13:33:38Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | A fucomannogalactan (FMG-Hm), with a molecular weight of 17.1 kDa, obtained from fruiting bodies of Hypsizygus marmoreus exhibited promising in vitro antimelanoma effects. FMG-Hm was not cytotoxic, nor did it alter the cell morphology and proliferation, but was able to inhibit colony-forming ability and cell migration in B16-F10 murine melanoma cells. An analysis of the monosaccharide composition indicated that FMG-Hm was composed of fucose, mannose, and galactose in a ratio of 1.00:1.08:3.17. The FMG-Hm was structurally characterized based on methylation analysis, partial acid hydrolysis, and NMR experiments. The results indicated that FMG-Hm contained a α-(1→6)-linked galactopyranosyl main chain, partially substituted at O-2 by non-reducing ends of α-L-fucopyranose and β-D-mannopyranose. The predicted structure of the heteropolysaccharide was established as: | |
| dc.identifier.citation | OLIVEIRA, Ruberney S. et al. Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus. Carbohydrate Polymers, Amsterdam, v. 225, e115203, 2019. DOI: 10.1016/j.carbpol.2019.115203. Disponível em: https://www.sciencedirect.com/science/article/pii/S0144861719308707?via%3Dihub. Acesso em: 16 fev. 2024. | |
| dc.identifier.doi | 10.1016/j.carbpol.2019.115203 | |
| dc.identifier.issn | 0144-8617 | |
| dc.identifier.issn | e- 1879-1344 | |
| dc.identifier.uri | http://repositorio.bc.ufg.br//handle/ri/24480 | |
| dc.language.iso | eng | |
| dc.publisher.country | Holanda | |
| dc.publisher.department | Instituto de Química - IQ (RMG) | |
| dc.rights | Acesso Aberto | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Hypsizygus marmoreus | |
| dc.subject | Mushroom | |
| dc.subject | Fucomannogalactan | |
| dc.subject | Chemical structure | |
| dc.subject | Antimelanoma | |
| dc.subject | B16-F10 cel | |
| dc.title | Structure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus | |
| dc.type | Artigo |