Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration
Carregando...
Data
2011
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
In recent years, stem cell research has grown exponentially owing to the recognition that stem cell-based therapies have the potential
to improve the life of patients with conditions that range from Alzheimer’s disease to cardiac ischemia and regenerative medicine, like
bone or tooth loss. Based on their ability to rescue and/or repair injured tissue and partially restore organ function, multiple types of
stem/progenitor cells have been speculated. Growing evidence demonstrates that stem cells are primarily found in niches and that certain
tissues contain more stem cells than others. Among these tissues, the dental tissues are considered a rich source of mesenchymal stem
cells that are suitable for tissue engineering applications. It is known that these stem cells have the potential to differentiate into several
cell types, including odontoblasts, neural progenitors, osteoblasts, chondrocytes, and adipocytes. In dentistry, stem cell biology and
tissue engineering are of great interest since may provide an innovative for generation of clinical material and/or tissue regeneration.
Mesenchymal stem cells were demonstrated in dental tissues, including dental pulp, periodontal ligament, dental papilla, and dental
follicle. These stem cells can be isolated and grown under defined tissue culture conditions, and are potential cells for use in tissue
engineering, including, dental tissue, nerves and bone regeneration. More recently, another source of stem cell has been successfully
generated from human somatic cells into a pluripotent stage, the induced pluripotent stem cells (iPS cells), allowing creation of patient-
and disease-specific stem cells. Collectively, the multipotency, high proliferation rates, and accessibility make the dental stem cell an
attractive source of mesenchymal stem cells for tissue regeneration. This review describes new findings in the field of dental stem cell
research and on their potential use in the tissue regeneration.
Descrição
Palavras-chave
Endodontics, Tissue engineering, Stem cell, Dental stem cell
Citação
ESTRELA, Carlos et al. Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration. Brazilian Dental Journal, Ribeirão Preto, v. 22, n. 2, p. 91-98, 2011.