B-mode and doppler ultrasonography in a murine model of ehrlich solid carcinoma with different growth patterns
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Data
2020
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Resumo
Ehrlich solid carcinoma (ESC) is one of the tumor models used in cancer research.
Although it is widely used, it has no ultrasonographic descriptions. In this study, serial Bmode
and Doppler ultrasonographic examinations were performed for 23 days for ESCs
inoculated into 18 Swiss albino mice. The growth patterns were analyzed, and on the
basis of their growth curve, the tumors were classified into two groups: fast growth (FG)
and slow growth (SG). Ultrasonographic characteristics of the tumor’s capsule, margins,
echogenicity, echotexture, vascular index (VI), distribution of vascular flow, and Doppler
indices such as the resistive index, pulsatility index, and peak systolic velocity (SV) were
analyzed and compared between the two groups. A high VI and earlier blood flow were
noted in the FG group (p<0.05). Additionally, SV was higher in the FG group than in the SG
group (13.28 ± 0.38 cm/s vs. 8.43 ± 0.26 cm/s). In contrast, a change in echogenicity and
flow distribution patterns were observed, especially in FG tumors. Therefore, ESC
presented with few ultrasonographic differences between FG and SG tumors,
especially vascularization during the initial stages of tumor growth.
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Ehrlich solid carcinoma, Growth pattern, Tumor vascularization, Comparative medicine, Ultrasound, Breast cancer
Citação
MARTÍ CASTELLÓ, Carla; MIGUEL, Marina Pacheco; SILVEIRA-LACERDA, Elisângela de Paula; BAKUZIS, Andris Figueiroa; BORGES, Naida Cristina. B-mode and doppler ultrasonography in a murine model of ehrlich solid carcinoma with different growth patterns. Frontiers in Oncology, Lausanne, v. 10, e560413, 2020. DOI: 10.3389/fonc.2020.560413. eCollection 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33251133/. Acesso em: 11 abr. 2023.