Angiogenic activity of Calendula officinalis flowers L. in rats
Data
2011
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Resumo
Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic
fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models
using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the
plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation
was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous
wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was
verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors.
Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis,
characterized by the induction of neovascularization
Descrição
Palavras-chave
Calendula, Medicinal, Wound healing, Rats, Plants, Neovascularization, Physiologic, Calendula, Cicatrização de feridas, Plantas medicinais, Ratos, Neovascularização fisiológica
Citação
PARENTE, Leila Maria Leal. Angiogenic activity of Calendula officinalis flowers L. in rats. Acta Cirurgica Brasileira, São Paulo, v. 26, n. 1, p. 19-24, 2011.