Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon

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dc.creatorCoutinho, Julia Penna
dc.creatorAguiar, Anna Caroline Campos
dc.creatorSantos, Pierre Alexandre dos
dc.creatorLima, Joaquim Corsino
dc.creatorRocha, Maria Gabrielle Lima
dc.creatorZani, Carlos Leomar
dc.creatorAlves, Tânia Maria Almeida
dc.creatorSantana, Antônio Euzébio Goulart
dc.creatorPereira, Maria de Meneses
dc.creatorKrettli, Antoniana Ursine
dc.date.accessioned2022-06-14T12:01:50Z
dc.date.available2022-06-14T12:01:50Z
dc.date.issued2013-12
dc.description.abstractInfusions of Aspidosperma nitidum (Apocynaceae) wood bark are used to treat fever and malaria in the Amazon Region. Several species of this family are known to possess indole alkaloids and other classes of secondary me tabolites, whereas terpenoids, an inositol and the indole alkaloids harmane-3 acid and braznitidumine have been described in A. nitidum. In the present study, extracts from the wood bark, leaves and branches of this species were prepared for assays against malaria parasites and cytotoxicity testing using human hepatoma and normal monkey kidney cells. The wood bark extracts were active against Plasmodium falciparum and showed a low cytotoxicity in vitro, whereas the leaf and branch extracts and the pure alkaloid braznitidumine were inactive. A crude methanol extract was subjected to acid-base fractionation aimed at obtaining alkaloid-rich fractions, which were active at low concentrations against P. falciparum and in mice infected with and sensitive Plasmodium berghei parasites. Our data validate the antimalarial usefulness of A. nitidum wood bark, a remedy that can most likely help to control malaria. However, the molecules responsible for this antimalarial activity have not yet been identified. Considering their high selectivity index, the alkaloid-rich fractions from the plant bark might be useful in the development of new antimalarialspt_BR
dc.identifier.citationCOUTINHO, Julia Penna et al. Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 108, n. 8, p. 974-982, Dec. 2013.  pt_BR
dc.identifier.doihttps://doi.org/10.1590/0074-0276130246 
dc.identifier.issn 0074-0276
dc.identifier.issne- 1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/20860
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAspidosperma nitidumpt_BR
dc.subjectSelectivity indexpt_BR
dc.subjectMedicinal plantspt_BR
dc.subjectPlasmodium falciparumpt_BR
dc.subjectHuman malariapt_BR
dc.titleAspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazonpt_BR
dc.typeArtigopt_BR

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