Graphene oxides coated paper as a substrate to paper spray ionization mass spectrometry for creatinine determination in urine samples
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Data
2019
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Resumo
Paper spray ionization (PSI) is a promising analytical tool for direct analysis in mass
spectrometry (MS). However, this technique usually uses chromatographic paper, which rarely
accomplishes a stable MS signal and could vary with the sample matrix effect. In the present study,
the application of graphene oxides (GO) was scrutinized as modifier paper substrate for PSI-MS
methods. The developed substrate efficiency was evaluated towards creatinine determination in
urine samples. The GO-PSI-MS developed method for creatinine in urine samples showed linearity
in the range of 0.1 to 3.4 ppm with R2 = 0.9991. The precision was evaluated and the values were
between 1.1 to 6.8% and the accuracy above 96.8%. The limit of quantification (LOQ) and limit
of detection (LOD) were 0.05 and 0.17 ppm, respectively. The GO-PSI developed was compared
to conventional chromatographic paper for PSI-MS methods, and the results showed that the
modified paper with GO bolsters method linearity, precision, and LOQ values.
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Paper spray ionization, Graphene oxide, Creatinine, Urine, Mass spectrometry
Citação
FERNANDES, Aline R.; BERNARDO, Ricardo A.; CARVALHO, Thays C. de; VAZ, Boniek G.; CHAVES, Andréa R. Graphene oxides coated paper as a substrate to paper spray ionization mass spectrometry for creatinine determination in urine samples. Journal of the Brazilian Chemical Society, Campinas, v. 30, n. 5, p. 1074-1081, 2019. DOI: 10.21577/0103-5053.20190007. Disponível em: https://jbcs.sbq.org.br/default.asp?ed=284. Acesso em: 17 maio 2023.