A volatolomic approach using cerumen as biofluid to diagnose bovine intoxication by Stryphnodendron rotundifolium

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dc.creatorBarbosa, João Marcos Gonçalves
dc.creatorRodrigues, Milenna Karoline Fernandes
dc.creatorDavid, Lurian Caetano
dc.creatorSilva, Taynara Cavalcante e
dc.creatorLima, Danielly Alves Fortuna
dc.creatorPereira, Naiara Zedes
dc.creatorD'Alessandro, Emmanuel Bezerra
dc.creatorOliveira, Anselmo Elcana de
dc.creatorFioravanti, Maria Clorinda Soares
dc.creatorAntoniosi Filho, Nelson Roberto
dc.date.accessioned2023-08-16T13:41:11Z
dc.date.available2023-08-16T13:41:11Z
dc.date.issued2020
dc.description.abstractAn innovative volatolomic approach employs the detection of biomarkers present in cerumen (earwax) to identify cattle intoxication by Stryphnodendron rotundifolium Mart., Fabaceae (popularly known as barbatimão). S. rotundifolium is a poisonous plant with the toxic compound undefined and widely distributed throughout the Brazilian territory. Cerumen samples from cattle of two local Brazilian breeds (‘Curraleiro Pé-Duro’ and ‘Pantaneiro’) were collected during an experimental intoxication protocol and analyzed using headspace (HS)/GC–MS followed by multivariate analysis (genetic algorithm for a partial least squares, cluster analysis, and classification and regression trees). A total of 106 volatile organic metabolites were identified in the cerumen samples of bovines. The intoxication by S. rotundifolium influenced the cerumen volatolomic profile of the bovines throughout the intoxication protocol. In this way, it was possible to detect biomarkers for cattle intoxication. Among the biomarkers, 2-octyldecanol and 9-tetradecen-1-ol were able to discriminate all samples between intoxicated and nonintoxicated bovines. The cattle intoxication diagnosis by S. rotundifolium was accomplished by applying the cerumen analysis using HS/GC–MS, in an easy, accurate, and noninvasive way. Thus, the proposed bioanalytical chromatography protocol is a useful tool in veterinary applications to determine this kind of intoxication.pt_BR
dc.identifier.citationBARBOSA, João Marcos G. et al. A volatolomic approach using cerumen as biofluid to diagnose bovine intoxication by Stryphnodendron rotundifolium. Biomedical Chromatography, Hoboken, v. 34, n. 11, e4935, 2020. DOI: 10.1002/bmc.4935. Disponível em: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/bmc.4935. Acesso em: 14 jun. 2023.pt_BR
dc.identifier.doi10.1002/bmc.4935
dc.identifier.issne- 1099-0801
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/bmc.4935
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBiomarkerspt_BR
dc.subjectClassification and regression treespt_BR
dc.subjectCluster analysispt_BR
dc.subjectGenetic algorithm for a partial least squarespt_BR
dc.subjectHS/GC–MSpt_BR
dc.subjectVolatile organic metabolitespt_BR
dc.titleA volatolomic approach using cerumen as biofluid to diagnose bovine intoxication by Stryphnodendron rotundifoliumpt_BR
dc.typeArtigopt_BR

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