Dantrolene e células-tronco mesenquimais promovem melhora funcional em ratos Wistar com trauma espinhal agudo
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2018-04
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This study aimed to evaluate the effects of dantrolene (DAN) and mesenchymal stem cells (MSCs) in acute spinal cord injury (SCI). Sixty Wistar rats were divided into groups MSCs, MSCs + DAN, DAN, trauma and placebo (TP) and no trauma and placebo (STP). Laminectomy was performed at T12 level in all animals, followed by a weight-drop model of SCI, except for the STP group. An hour later, the MSCs + DAN and DAN groups received 10mg/kg of DAN. After seven days, the MSCs and MSCs + DAN groups received 1x106 cells intravenously. Behavioral tests were performed to assess functional recovery for 28 days. Traumatized animals showed paraplegia. There was a significant improvement in groups MSCs, DAN and MSCs + DAN compared to TP (p<0.05). It was concluded that DAN and MSCs for the treatment of SCI in rats have neuroprotection effect and promote functional neurological improvement.
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Dantrolene, Células-tronco mesenquimais, Recuperação funcional, Ratos Wistar, Trauma espinhal agudo, Traumatismos da medula espinal, Terapia celular, Bloqueadores dos canais de cálcio, Escala de avaliação comportamental, Ratos, Mesenchymal stem cells, Functional improvement, Wistar rats, Spinal cord injury, Cellular therapy, Calcium channel blockers, Behavior rating scale, Rats
Citação
TORRES, B. B. J. et al. Dantrolene e células-tronco mesenquimais promovem melhora funcional em ratos Wistar com trauma espinhal agudo. Pesquisa Veterinária Brasileira, Seropédica, v. 38, n. 4, p. 703–709, 2018. DOI: 10.1590/1678-5150-PVB-5165. Disponível em: https://www.scielo.br/j/pvb/a/WhCRmHrxsSPC5DSJWVpBcNc/?lang=pt. Acesso em: 02 jun. 2025.