Novel sulfonamide-chalcone hybrid stimulates inflammation, angiogenesis and upregulates vascular endothelial growth factor (VEGF) in vivo

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dc.creatorSilva, Luana Santos
dc.creatorVéras, Jefferson Hollanda
dc.creatorFernandes, Amanda Silva
dc.creatorMelo Bisneto, Abel Vieira de
dc.creatorCastro, Mirian Rita Carrilho de
dc.creatorNaves, Raquel Ferreira
dc.creatorCarneiro, Cristiene Costa
dc.creatorNoda Pérez, Caridad
dc.creatorCardoso, Cléver Gomes
dc.creatorSilva, Carolina Ribeiro e
dc.creatorLee, Chen Chen
dc.date.accessioned2023-08-21T13:02:15Z
dc.date.available2023-08-21T13:02:15Z
dc.date.issued2022
dc.description.abstractChalcones and sulfonamides are well-known chemical groups associated with several biological activities such as antibiotic, anti-inflammatory, and antitumor activities. Over the past few decades, a series of sulfonamide-chalcone hybrids have been synthesized and assessed to develop compounds with interesting biological properties for application in disease therapy. In the present study, a new sulfonamide-chalcone hybrid μ - (2,5-dichloro-N-{4-[(3E)-4-(3-nitrophenyl) buta-1,3-dien-2-yl] phenyl} benzene sulfonamide), or simply CL185, was synthesized, and its angiogenic activity was assessed using the chick embryo chorioallantoic membrane (CAM) assay at different concentrations (12.5, 25, and 50 μg/μL). To further investigate the role of CL185 in the angiogenic process, we evaluated the levels of vascular endothelial growth factor (VEGF) in all treated CAMs. The results showed that all concentrations of CL185 significantly increased tissue vascularization (p < 0.05) as well as the parameters associated with angiogenesis, in which inflammation was the most marked phenomenon observed. In all CAMs treated with CL185, VEGF levels were significantly higher than those in the negative control (p < 0.05), and at the highest concentration, VEGF levels were even higher than in the positive control (p < 0.05). The pronounced angiogenic activity displayed by CL185 may be related to the increase in VEGF levels that were stimulated by inflammatory processes observed in our study. Therefore, CL185 presents a favorable profile for the development of drugs that can be used in pro-angiogenic and tissue repair therapies.pt_BR
dc.identifier.citationSILVA, Luana Santos et al. Novel sulfonamide-chalcone hybrid stimulates inflammation, angiogenesis and upregulates vascular endothelial growth factor (VEGF) in vivo. Microvascular Research, Amsterdam, v. 139, e104253, 2022. DOI: 10.1016/j.mvr.2021.104253. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0026286221001230?via%3Dihub. Acesso em: 17 ago. 2023.pt_BR
dc.identifier.doi10.1016/j.mvr.2021.104253
dc.identifier.issne- 1095-9319
dc.identifier.issn0026-2862
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0026286221001230?via%3Dihub
dc.language.isoengpt_BR
dc.publisher.countryHolandapt_BR
dc.publisher.departmentInstituto de Química - IQ (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleNovel sulfonamide-chalcone hybrid stimulates inflammation, angiogenesis and upregulates vascular endothelial growth factor (VEGF) in vivopt_BR
dc.typeArtigopt_BR

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