Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation
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Data
2022
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Purpose: Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic,
osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25%
of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats’ wounds. Methods: One hundred
and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v
(G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and
21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear
and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen. Results: The therapeutic treatment with cream gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation
of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher
rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the
injured tissues. Conclusion: H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.
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Collagen, Rats, Wound healing, Apocynaceae
Citação
D’ABADIA, Patrícia Lima et al. Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation. Acta Cirúrgica Brasileira, São Paulo, v. 37, n. 10, e371001, 2022. DOI: 10.1590/acb371001. Dsiponível em: https://www.scielo.br/j/acb/a/cRFBFLqmbB8TZzv5jM95Z3M/?lang=en. Acesso em: 4 maio 2023.