Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies

Vaz, Wesley Fonseca; Custodio, Jean Marcos Ferreira; D´Oliveira, Giulio Demetrius Creazzo; Neves, Bruno Junior; Carvalho Júnior, Paulo de Sousa; Moreira Filho, José Teófilo; Andrade, Carolina Horta; Noda Pérez, Caridad; Lacerda, Elisângela de Paula Silveira; Napolitano, Hamilton Barbosa

Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies

Data

2021

Autores

Vaz, Wesley Fonseca

Custodio, Jean Marcos Ferreira

D´Oliveira, Giulio Demetrius Creazzo

Neves, Bruno Junior

Carvalho Júnior, Paulo de Sousa

Moreira Filho, José Teófilo

Andrade, Carolina Horta

Noda Pérez, Caridad

Lacerda, Elisângela de Paula Silveira

Napolitano, Hamilton Barbosa

Resumo

Cancer is one of the leading causes of death worldwide and requires intense and growing research investments from the public and private sectors. This is expected to lead to the development of new medicines. A determining factor in this process is the structural understanding of molecules with potential anticancer properties. Since the major compounds used in cancer therapies fail to encompass every spectrum of this disease, there is a clear need to research new molecules for this purpose. As it follows, we have studied the class of quinolinones that seem effective for such therapy. This paper describes the structural elucidation of a novel dihydroquinoline by single-crystal X-ray diffraction and spectroscopy characterization. Topology studies were carried through Hirshfeld surfaces analysis and molecular electrostatic potential map; electronic stability was evaluated from the calculated energy of frontier molecular orbitals. Additionally, in silico studies by molecular docking indicated that this dihydroquinoline could act as an anticancer agent due to their higher binding affinity with human aldehyde dehydrogenase 1A1 (ALDH 1A1). Tests in vitro were performed for VERO (normal human skin keratinocytes), B16F10 (mouse melanoma), and MDA-MB-231 (metastatic breast adenocarcinoma), and the results certified that compound as a potential anticancer agent.

Palavras-chave

X-ray diffraction, Molecular docking, ADMET properties, Hirshfeld surface, Anticancer activity

Citação

VAZ, W. F. et al. Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies. Molecular Diversity, Dordrecht, v. 25, p. 55-66, 2021. DOI: 10.1007/s11030-019-10024-x. Disponível em: https://link.springer.com/article/10.1007/s11030-019-10024-x. Acesso em: 17 ago. 2023.