Multiresponse optimization of an extraction procedure of carnosol and rosmarinic and carnosic acids from rosemary
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2016
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Resumo
A green solvent-based optimization for rosmarinic acid (RA), carnosol (COH), and carnosic acid (CA)
extraction, the three main antioxidants from rosemary, was performed. The conventional solid-liquid
extraction was optimized using a central composite design (CCD) followed by the desirability approach.
In the CCD analysis the quantitative effects of extraction time (4.8–55.2 min), liquid-to-solid ratio
(4.6–21.4 mL g-¹ ), and ethanol content (44.8–95.2% v/v) were determined for the extracted amount of
antioxidants, their concentrations in the extract, and the extraction yield. Samples were analyzed by
HPLC and the antioxidants were identified by comparison with pure standard retention times and UV
spectra. The desirability function that simultaneously maximizes the antioxidants extraction and their
concentrations in the final product was validated. The extraction using a hydroalcoholic solution 70%
v/v, at low liquid-to-solid ratio (5 mL g-¹), and after 55-min yielded an antioxidant recovery rate of
89.8%, and a final product 4.75 times richer in the main antioxidants than the raw material.
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Rosemary, Antioxidants, Conventional extraction, RSM, Desirability function
Citação
OLIVEIRA, Gerlon de A. R.; OLIVEIRA, Anselmo E. de; CONCEIÇÃO, Edemílson C. da; LELES, Maria I. G. Multiresponse optimization of an extraction procedure of carnosol and rosmarinic and carnosic acids from rosemary. Food Chemistry, Amsterdam, v. 211, p. 465-473, 2016. DOI: 10.1016/j.foodchem.2016.05.042. Disponível em: https://www.sciencedirect.com/science/article/pii/S0308814616307233?via%3Dihub. Acesso em: 14 jun. 2023.