Human papillomavirus and anal cancer: prevalence, genotype distribution, and prognosis aspects from midwestern region of Brazil
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2019
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d. Approximately 90% of all anal cancers are associated with human papillomavirus (HPV), especially high-risk
genotypes such as HPVs 16 and 18. Objective. To investigate the clinical and prognostic aspects of anal cancers associated
with the presence, as well as the genotypic distribution of human papillomavirus (HPV). Methods. A retrospective study
carried out over a 10-year period, using clinical and molecular data, with PCR analysis and reverse hybridization (INNO LIPA kit), in anal cancers. ,e data analysis was done using descriptive univariate statistics, and the survival curves were
made using the Kaplan–Meier and log-rank methods. Results. Of the 81 formalin-fixed and paraffin-embedded specimens,
HPV prevalence was 69% and was significantly higher in squamous cell carcinomas (SCC) than in other anal tumors
(p � 0.0001). Female patients had a higher prevalence of HPV (p � 0.01). Multiple infections were detected in 14.3% of cases.
,e most prevalent genotypes were HPVs 16, 33, and 18. ,e overall survival at 60 months was 44.3%, and the prognostic
factors included gender (p � 0.008) with greater survival for men (52.9%) in comparison to women (29.6%), histological
type (p � 0.01), SCC (54.4%), adenocarcinomas (37.5%), other carcinomas (14.2%), and the presence of distant metastasis
(p � 0.01). Survival was not influenced by the presence of HPV (p � 0.54). Conclusions. ,e association of HPV to anal
cancer was found in this study, especially in SCC. However, the presence of HPV did not influence the prognosis of patients
with anal cancer.
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LIBERA, Larisse Silva Dalla et al. Human papillomavirus and anal cancer: prevalence, genotype distribution, and prognosis aspects from midwestern region of Brazil. Journal of Oncology, Cairo, v. 2019, e6018269, 2019. DOI: 10.1155/2019/6018269. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31641354/. Acesso em: 14 abr. 2025.