Comparação do perfil de anticorpos antiimunoglobulina G em murinos imunizados com IgG humana associada a diferentes adjuvantes

Resumo

Adjuvants are substances associated with antigens that increase or modify the imune response. This work/study is a comparison of the profile of murine antibodies in groups immunized with human IgG associated or not with adjuvants, using the Enzyme Linked Immunosorbent Assay (ELISA) technique in the 28th and 40th days after immunization. The adjuvants evaluated in this work/study were the aluminium hydroxide and Freund’s adjuvant. The results showed that in 28th day the mice immunizad with adjuvants exhibited higher values of absorbance compared with the animals immunized without adjuvants. However, it was found that the murine immunized with aluminium hydroxide and Freund’s adjuvant showed similar values of optical density. In contradiction, in the 40th day the groups of mice examined showed analogues profiles of anti-human IgG.

Descrição

Palavras-chave

Adjuvantes imunológicos, Imunização, Anti – IgG humana, Immunological adjuvants, Immunization, Anti-human IgG

Citação

NUNES, Marcus Vinicius Oliveira; SOUSA, Camila Pereira Câmara; CRESPO, Adriana de Moraes Costa; CARVALHAES, Mara; OLIVEIRA, Cristina Rodrigues de; SILVEIRA, Lucimeire Antonelli da. Comparação do perfil de anticorpos antiimunoglobulina G em murinos imunizados com IgG humana associada a diferentes adjuvantes. Revista Eletrônica de Farmácia, Goiânia, v. 6, n. 1, p. 44-50, abr./jun. 2009. Disponível em: <https://revistas.ufg.br/REF/article/view/5860/4560>.