Lab-made solid phase microextraction phases for off line extraction and direct mass spectrometry analysis: evaluating the extraction parameters
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2019
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The analyses of drugs and metabolites in complex matrices have been widely studied in recent years. However, due to high levels endogenous compounds and matrix complexity, these analyses require a sample pre-treatment step. To this aim, two lab-made extractive phases were integrated to probe electrospray ionization mass spectrometry (PESI-MS) technique for direct analysis of illicit drugs in biological fluids and phorbol esters in Jatropha curcas extract. The polypyrrole (PPy) phase was electropolymerized onto a platinum wire surface by cyclic voltammetry. The molecularly imprinted polymer (MIP) was synthesized and adhered onto a stainless-steel needle with epoxy resin. The PPy-PESI-MS method showed to be linear in a concentration range from 1 to 500 μg L−¹, with accuracy values between -2.1 and 14%, and precision values between 0.8 and 10.8%. The MIP-PESI-MS method showed to be linear in a concentration range from 0.9 to 30 mg L−¹, with accuracy values between -1.6 and -15.3%, and precision values between 4.1 and 13.5%.
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BERNARDO, Ricardo Alves et al. Lab-made solid phase microextraction phases for off line extraction and direct mass spectrometry analysis: evaluating the extraction parameters. Journal of Chromatography A, Amsterdam, v. 1603, p. 23-32, 2019. DOI: 10.1016/j.chroma.2019.06.038. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0021967319306478?via%3Dihub. Acesso em: 28 jun. 2023.