AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats

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dc.creatorPróspero, André Gonçalves
dc.creatorOliveira, Patrícia Fidelis de
dc.creatorSoares, Guilherme Augusto
dc.creatorMiranda, Milena F.
dc.creatorPinto, Leonardo Antonio
dc.creatorSouza, Daniela Cristina dos
dc.creatorSilva, Vanessa dos Santos
dc.creatorZufelato, Nícholas
dc.creatorBakuzis, Andris Figueiroa
dc.creatorMiranda, José Ricardo de Arruda
dc.date.accessioned2023-11-21T14:36:27Z
dc.date.available2023-11-21T14:36:27Z
dc.date.issued2020
dc.description.abstractAim: This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys. Materials & methods: We used the ACB to detect the MNP kidney perfusion in vivo. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution. Results: We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved. Conclusion: This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine.
dc.identifier.citationPROSPERO, Andre G et al. AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats. Nanomedicine, London, v. 15, n. 5, p. 511-525, 2020. DOI: 10.2217/nnm-2019-0300. Disponível em: https://www.futuremedicine.com/doi/10.2217/nnm-2019-0300?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed. Acesso em: 12 set. 2023.
dc.identifier.doi10.2217/nnm-2019-0300
dc.identifier.issn1743-5889
dc.identifier.issne- 1748-6963
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/nnm-2019-0300?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.language.isoeng
dc.publisher.countryGra-bretanha
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Restrito
dc.subjectBiomagnetism
dc.subjectChronic kidney disease
dc.subjectDoxorubicin
dc.subjectMagnetic nanoparticles
dc.subjectNanomedicine
dc.subjectRenal perfusion
dc.titleAC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats
dc.typeArtigo

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