Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach

Página do item simplificado
dc.creatorFranco, Fernanda Craveiro
dc.creatorAlves, Alessandro Arruda
dc.creatorGodoy, Fernanda Ribeiro
dc.creatorAvelar, Juliana Boaventura
dc.creatorRodrigues, Douglas Dantas
dc.creatorPedroso, Thays Millena Alves
dc.creatorCruz, Aparecido Divino da
dc.creatorNomura, Fausto
dc.creatorSilva, Daniela de Melo e
dc.date.accessioned2023-06-29T13:39:36Z
dc.date.available2023-06-29T13:39:36Z
dc.date.issued2016
dc.description.abstractThis is the first study demonstrating genotoxic effects and whole transcriptome analysis on community health agents (CHAs) occupationally exposed to pesticides in Central Brazil. For the transcriptome analysis, we found some genes related to Alzheimer's disease (LRP1), an insulin-like growth factor receptor (IGF2R), immunity genes (IGL family and IGJ), two genes related to inflammatory reaction (CXCL5 and CCL3), one gene related to maintenance of cellular morphology (NHS), one gene considered to be a strong apoptosis inductor (LGALS14), and several transcripts of the neuroblastoma breakpoint family (NBPF). Related to comet assay, we demonstrated a significant increase in DNA damage, measured by the olive tail moment (OTM), in the exposed group compared to the control group. Moreover, we also observed a statistically significant difference in OTM values depending on GSTM1 genotypes. Therefore, Brazilian epidemiological surveillance, an organization responsible for the assessment and management of health risks associated to pesticide exposure to CHA, needs to be more proactive and considers the implications of pesticide exposure for CHA procedures and processes.pt_BR
dc.identifier.citationFRANCO, Fernanda Craveiro et al. Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach. Environmental Science and Pollution Research International, Berlim, v. 23, n. 19, p. 19723-19734, 2016. DOI: 10.1007/s11356-016-7179-y. Disponível em: https://pubmed.ncbi.nlm.nih.gov/27406225/. Acesso em: 6 jun. 2023.pt_BR
dc.identifier.doi10.1007/s11356-016-7179-y
dc.identifier.issn0944-1344
dc.identifier.issne- 1614-7499
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/27406225/
dc.language.isoengpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RMG)pt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectComet assaypt_BR
dc.subjectPesticide genotoxicitypt_BR
dc.subjectDNA damagept_BR
dc.subjectGST genotypespt_BR
dc.subjectDifferential expression panelpt_BR
dc.subjectOccupational exposurept_BR
dc.titleEvaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approachpt_BR
dc.typeArtigopt_BR

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

ICB - Artigos publicados em periódicos