Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)

Página do item simplificado
dc.creatorSpíndula Filho, José Vieira de
dc.creatorCruz, Aparecido Divino da
dc.creatorLeite, Angélica Ferreira Oton
dc.creatorLeles, Cláudio Rodrigues
dc.creatorAlencar, Rita de Cássia Gonçalves de
dc.creatorSaddi, Vera Aparecida
dc.creatorMendonça, Elismauro Francisco de
dc.date.accessioned2020-02-14T10:11:08Z
dc.date.available2020-02-14T10:11:08Z
dc.date.issued2011
dc.description.abstractHuman papillomavirus (HPV) has been cited as a possible initiating agent in the pathogenesis of oral cancer. However, the literature tends to be both controversial and inconclusive about the prevalence of HPV and its potential for proliferation in oral squamous cell carcinoma (SCC). The aim of this study was to investigate the cellular proliferation and the presence of HPV in SCC and verrucous carcinoma (VC). Forty-seven samples of SCC were selected and divided into three groups: 39 SCC, 8 VC, and 9 of normal mucosa (control-CT). Quantitative analyses of all groups showed a greater expression of PCNA, followed by Ki-67 and cyclin B1. A significant difference was observed in cyclin B1 expression in the SCC group compared with VC. PCNA, Ki-67, and cyclin B1 were statistically significant when comparing the SCC and CT groups. However, when SCC and VC were compared, there was no difference in Ki-67 expression. Our results showed that only cyclin B1 had an association with histological grade, and that poorly differentiated tumors presented a higher expression of cyclin B1. Therefore, considerable differences in the cellular proliferation between SCC and VC were observed, and no correlation with HPV was established, since all samples were negative for HPV.pt_BR
dc.identifier.citationSPÍNDULA-FILHO, José Vieira et al. Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV). Tumor Biology, New York, v. 32, n. 2, p. 409-416, 2011.pt_BR
dc.identifier.doi10.1007/s13277-010-0135-4
dc.identifier.issn1010-4283
dc.identifier.issne- 1423-0380
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18687
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentFaculdade de Odontologia - FO (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.subjectHPVpt_BR
dc.subjectOral verrucous carcinomapt_BR
dc.subjectCyclin B1pt_BR
dc.subjectPCNApt_BR
dc.subjectKi-67pt_BR
dc.titleOral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)pt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - José Vieira de Spíndula Filho - 2011.pdf
Tamanho:
482.31 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

FO - Artigos publicados em periódicos