New prospects in neutering male animals using magnetic nanoparticle hyperthermia
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2021
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Resumo
Controlling populations of free-roaming dogs and cats poses a huge challenge worldwide.
Non-surgical neutering strategies for male animals have been long pursued, but the implementation
of the procedures developed has remained limited to date. As submitting the testes to high temperatures
impairs spermatogenesis, the present study investigated localized application of magnetic
nanoparticle hyperthermia (MNH) to the testicles as a potential non-surgical sterilization method for
animals. An intratesticular injection of a magnetic fluid composed of manganese-ferrite nanoparticles
functionalized with citrate was administered followed by testicle exposure to an alternate magnetic
field to generate localized heat. Testicular MNH was highly effective, causing progressive seminiferous
tubule degeneration followed by substitution of the parenchyma with stromal tissue and gonadal
atrophy, suggesting an irreversible process with few side effects to general animal health.
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Infertility, Nanocontraception, Testicles, Magnetohyperthermia, Spermatogenesis
Citação
JIVAGO, José Luiz P. R. et al. New prospects in neutering male animals using magnetic nanoparticle hyperthermia. Pharmaceutics, Basel, v. 13, n. 9, e1465, 2021. DOI: 10.3390/pharmaceutics13091465. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467495/. Acesso em: 11 abr. 2023.