A comparative study on active and passive epidemiological surveillance for dengue in five countries of Latin America
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2016
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Background: Dengue is a notifiable infectious disease in many countries, but under-reporting of cases to
National Epidemiological Surveillance Systems (NESSs) conceals the true extent of the disease burden.
The incidence of dengue identified in a cohort study was compared with those reported to NESSs.
Methods: A randomized, placebo-controlled study was undertaken in Brazil, Colombia, Honduras,
Mexico, and Puerto Rico to assess the efficacy of a tetravalent dengue vaccine (CYD-TDV) in children aged
9–16 years. The incidence of dengue in the placebo group was compared with that reported to NESSs in a
similar age group (10–19 years) from June 2011 to April 2014.
Results: Three thousand six hundred and fifteen suspected dengue cases were identified in the study
over 13 527 person-years of observation. The overall incidence of confirmed dengue was 2.9 per
100 person-years (range 1.5 to 4.1 per 100 person-years). In the NESSs combined, over 3.2 million
suspected dengue cases were reported during the same period, corresponding to over 1 billion person years of observation. The incidence of confirmed dengue reported by the NESSs in the same locality
where the study took place was 0.286 per 100 person-years across Brazil, Colombia, and Mexico (range
0.180 to 0.734 per 100 person-years). The incidence of confirmed dengue was 10.0-fold higher in the
study than that reported to NESSs in the same localities (range 3.5- to 19.4-fold higher).
Conclusions: There is a substantial under-reporting of dengue in the NESSs. Understanding the level of
under-reporting would allow more accurate estimates of the dengue burden in Latin America.
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Dengue, Flavivirus, Surveillance, Epidemiology, South America
Citação
SARTI, Elsa et al. A comparative study on active and passive epidemiological surveillance for dengue in five countries of Latin America. International Journal of Infectious Diseases, Hamilton, v. 44, p. 44-49, 2016. DOI: 10.1016/j.ijid.2016.01.015. Disponível em: https://www.sciencedirect.com/science/article/pii/S1201971216000163?via%3Dihub. Acesso em: 20 jan. 2025.1201-9712.