Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens

Terezan, Ana Paula; Junqueira, João Gabriel Moraes; Wakui, Vinícius Galvão; Kato, Lucilia; Oliveira, Cecilia Maria Alves de; Martins, Carlos Henrique Gomes; Santiago, Mariana Brentini; Severino, Vanessa Gisele Pasqualotto

Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens

Data

2022

Autores

Terezan, Ana Paula

Junqueira, João Gabriel Moraes

Wakui, Vinícius Galvão

Kato, Lucilia

Oliveira, Cecilia Maria Alves de

Martins, Carlos Henrique Gomes

Santiago, Mariana Brentini

Severino, Vanessa Gisele Pasqualotto

Resumo

Araticum is an edible and appreciable fruit of Annona coriacea, which is popularly known as a traditional herb in the Brazilian cerrado. A phytochemical study from the leaves of A. coriacea showed that HPLC-ESI-Q-Orbitrap® provided through PRM experiments (MS²) is an efficient method for the fast and accurate analysis of a complex mixture of annonaceous acetogenins, with the identification of sylvaticin and gigantetrocin-A type acetogenins for the first time. In addition, the crude leaf extract and acetogenin-rich fractions were assayed against Streptococcus mutans, S. mitis, S. sanguinis and S. salivarius strains, which are usually related to oral infections.

Palavras-chave

Annona coriacea, Acetogenin, HPLC, ESI-HRMS, Antibacterial activity

Citação

TEREZAN, Ana Paula et al. Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens. Natural Product Research, Abingdon, v. 36, n. 3, p. 765-771, 2022. DOI: 10.1080/14786419.2020.1803312. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14786419.2020.1803312. Acesso em: 28 ago. 2023.