Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens

Resumo

Araticum is an edible and appreciable fruit of Annona coriacea, which is popularly known as a traditional herb in the Brazilian cerrado. A phytochemical study from the leaves of A. coriacea showed that HPLC-ESI-Q-Orbitrap® provided through PRM experiments (MS²) is an efficient method for the fast and accurate analysis of a complex mixture of annonaceous acetogenins, with the identification of sylvaticin and gigantetrocin-A type acetogenins for the first time. In addition, the crude leaf extract and acetogenin-rich fractions were assayed against Streptococcus mutans, S. mitis, S. sanguinis and S. salivarius strains, which are usually related to oral infections.

Descrição

Palavras-chave

Annona coriacea, Acetogenin, HPLC, ESI-HRMS, Antibacterial activity

Citação

TEREZAN, Ana Paula et al. Qualitative analysis of the acetogenins from Annona coriacea (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens. Natural Product Research, Abingdon, v. 36, n. 3, p. 765-771, 2022. DOI: 10.1080/14786419.2020.1803312. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14786419.2020.1803312. Acesso em: 28 ago. 2023.