Estudo do leucograma como monitor do 2-1 fosfato dissódico de betametasona e do fosfato dissódico/acetato de dexametasona, em cães que receberam transplantes com córneas de suínos

Abstract

Ten mixedbreeddogs, with a 10 kg average weigth were selected at Centro de Zoonoses de Goiânia. After being examined and considered healthy, the dogs were enumerated from 11 to 20 on their collars. Each animal had swine comea implanted into the left eye. Toe swine comea was obtained at Casa de Banha Caçula, a slaughterhouse, and conserved in humid chamber during a maximum 6 hour period. Each animal received 4 mg dissodic fosphate/acetate dexamethasone IM and was instilled one drop of gentamycin sulphatelbetamethasone dissodic fosphate, mantaining ocular medication 4 times/day and intramuscular medication once a week until euthanasia. Each animal had blood sample collected on day O, before surgery, and on day 14 and 28 to analyse white blood count as a monitor of corticosteroids, imunocellu­lar supressor drugs. From ten blood samples collected on day O, 80% didn't present any alterations, 10"/o presented leukocytosis with neutrophilia and 10% weren't submitted to analysis. Due to the fact that three animais had ben euthaniz.ed between days 14 and 21, these samples (40%), were analized and compared with these collected on day O. Five animais (50%) had their samples examined on day 28. 0n both days 14 and 28, there were 100% neutrophilia, 100% eosinophilia and 44,4% Jymphocytopenia, indicating imunocellular supression.