Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension

Página do item simplificado
dc.creatorBlanch, Graziela Torres
dc.creatorOliveira, André Henrique Freiria de
dc.creatorSperetta, Guilherme Fleury Fina
dc.creatorCarrera, Eduardo J.
dc.creatorHongwei, Li
dc.creatorSpeth, Robert C.
dc.creatorColombari, Eduardo
dc.creatorSumners, Colin
dc.creatorColombari, Débora Simões de Almeida
dc.date.accessioned2018-08-21T11:03:29Z
dc.date.available2018-08-21T11:03:29Z
dc.date.issued2014-10
dc.description.abstractAngiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin–angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary–vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the vagus), a key brain stem region for cardiovascular regulation, on the development of renovascular hypertension. Holtzman normotensive rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip renovascular hypertension. Three weeks later, rats were microinjected in the solitary–vagal complex with either an adenoassociated virus to increase the expression of angiotensin type 2 receptors or with a control vector. We observed that increasing angiotensin type 2 receptor expression in the solitary–vagal complex attenuated the development of renovascular hypertension and also reversed the impairment of the baroreflex and the increase in the low-frequency component of systolic blood pressure observed in renovascular hypertensive rats. Furthermore, an observed decrease in mRNA levels of angiotensin-converting enzyme 2 in the solitary–vagal complex of renovascular hypertensive rats was restored to control levels after viral-mediated increases in angiotensin type 2 receptors at this site. Collectively, these data demonstrate specific and beneficial effects of angiotensin type 2 receptors via the brain of hypertensive rats and suggest that central angiotensin type 2 receptors may be a potential target for therapeutics in renovascular hypertension.pt_BR
dc.identifier.citationBLANCH, Graziela Torres; FREIRIA-OLIVEIRA, André Henrique; SPERETTA, Guilherme Fleury Fina; CARREIRA, Eduardo J.; HONGWEI, Li; SPETH, Robert C.; COLOMBARI, Eduardo; SUMNERS, Colin; COLOMBARI, Débora S. A. Increased expression of angiotensin ii type 2 receptors in the solitary-vagal complex blunts renovascular hypertension. Hypertension, Dallas, v. 64, p. 777-783, Oct. 2014.pt_BR
dc.identifier.doi10.1161/HYPERTENSIONAHA.114.03188
dc.identifier.issn0194-911X
dc.identifier.issne- 1524-4563
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15677
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAngiotensin IIpt_BR
dc.subjectAngiotensin-converting enzyme 2pt_BR
dc.subjectAngiotensin receptor blockerspt_BR
dc.subjectBaroreflexpt_BR
dc.titleIncreased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertensionpt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - Graziela Torres Blanch - 2014.pdf
Tamanho:
987.63 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

ICB - Artigos publicados em periódicos