Effect of tamoxifen and raloxifene on the proliferative activity of the breast epithelium in premenopausal women

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dc.creatorLucato, Miliana Tostes
dc.creatorFreitas Júnior, Ruffo de
dc.creatorMoreira, Marise Amaral Rebouças
dc.creatorBernardes Júnior, Júlio Roberto de Macedo
dc.creatorPinto, Sebastião Alves
dc.creatorPaulinelli, Régis Resende
dc.creatorSoares, Leonardo Ribeiro
dc.date.accessioned2019-08-30T12:49:04Z
dc.date.available2019-08-30T12:49:04Z
dc.date.issued2015
dc.description.abstractObjectives: To compare the effects of tamoxifen and raloxifene on the proliferative activity of normal breast tissue in premenopausal women as measured by Ki-67/MIB-1 expression. Study design: A total of 48 women with benign breast nodules and a recommendation for surgical removal of the lesion took part in this study. They were randomized to use tamoxifen or raloxifene for 22 days, after which they were submitted to surgery. During the surgical procedure, a 1-cm fragment of normal breast tissue was removed to study Ki-67 expression. Results: The mean percentage ratios between immunolabeled and non-labeled cells were 2.02 ± 1.09 and 3.13 ± 3.23 for the tamoxifen and raloxifene groups, respectively. There was no statistically significant difference between the tamoxifen (n = 16) and raloxifene (n = 14) groups in relation to the immuno­ histochemical analysis of Ki-67 (P = 0.205). Conclusion: The results of this study showed no difference between tamoxifen and raloxifene with respect to the potential of these drugs to reduce the proliferative activity of the normal breast epithelium in premenopausal women.pt_BR
dc.identifier.citationLUCATO, Miliana T. et al. Effect of tamoxifen and raloxifene on the proliferative activity of the breast epithelium in premenopausal women. Clinical Medicine Insights: oncology, London, v. 9, p. 25-30, 2015.pt_BR
dc.identifier.doi10.4137/CMO.S22456
dc.identifier.issn1179-5549
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18060
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBreast epitheliumpt_BR
dc.subjectTamoxifenpt_BR
dc.subjectBreastpt_BR
dc.subjectRaloxifenept_BR
dc.subjectKi-67pt_BR
dc.subjectPremenopausal womenpt_BR
dc.titleEffect of tamoxifen and raloxifene on the proliferative activity of the breast epithelium in premenopausal womenpt_BR
dc.typeArtigopt_BR

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