Natural organic acid as green catalyst for xanthenones synthesis: methodology, mechanism and calcium channel blocking activity

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dc.creatorDiniz , Bruna Silva Terra
dc.creatorBlandón Osorio, Aura María
dc.creatorOliveira, Aline de
dc.creatorMouro, Andressa Pereira
dc.creatorAraújo, Natália Ferreira de
dc.creatorSilva, Cameron Capeletti da
dc.creatorMartins, Felipe Terra
dc.creatorVieira , Luciene Bruno
dc.creatorBonaventura, Daniella
dc.creatorAbreu, Heitor Avelino de
dc.creatorAlcântara, Antônio Flávio de Carvalho
dc.creatorFátima, Ângelo de
dc.date.accessioned2023-12-05T12:13:21Z
dc.date.available2023-12-05T12:13:21Z
dc.date.issued2017
dc.description.abstractXanthenones were synthesized via one-pot tricomponent reaction, under solvent-free conditions, using aldehydes, phenolic and cyclic 1,3-dicarbonyl compounds. Natural organic acids (NOAs), compounds present in many living metabolisms, were used as potential green catalysts. NOA are considered to be more eco-friendly and user-friendly alternative to traditional methodologies. Optimization studies showed that oxalic acid was the best NOA catalyst for such reaction furnishing the xanthenones with up to 93% of yield. Theoretical calculations were performed to evaluate this reaction mechanism and regioselectivity. The results showed that the regiospecificity of this three-component reaction is kinetically and thermodynamically controlled by the addition of b-naphthol C2, instead of C10, to the aldehyde. Our results also disclosed two xanthenones as novel calcium channels blockers. Eco-friendly reaction conditions, easy workup procedure, short reaction times and good yields are some of the advantages of our methodology.
dc.identifier.citationTERRA, Bruna S. et al. Natural organic acid as green catalyst for xanthenones synthesis: methodology, mechanism and calcium channel blocking activity. Journal of the Brazilian Chemical Society, Campinas, v. 28, n. 12, p. 2313-2325, 2017. DOI: 10.21577/0103-5053.20170082. Disponível em: https://jbcs.sbq.org.br/default.asp?ed=260. Acesso em: 30 nov. 2023.
dc.identifier.doi10.21577/0103-5053.20170082
dc.identifier.issn0103-5053
dc.identifier.issne- 1678-4790
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/23902
dc.language.isoeng
dc.publisher.countryBrasil
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectXanthenones
dc.subjectNatural organic acid
dc.subjectTheoretical calculations
dc.subjectCalcium channels blockers
dc.titleNatural organic acid as green catalyst for xanthenones synthesis: methodology, mechanism and calcium channel blocking activity
dc.typeArtigo

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