Avaliação da toxicidade aguda e subaguda, em ratos, do extrato etanólico das folhas e do látex de Synadenium umbellatum Pax
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Data
2009-06
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Resumo
The use of medicinal plants has been being
very significant in the last years, being the use encouraged by WHO. Synadenium umbellatum Pax,
Euphorbiacea (popularly known as cola-note, cancerola, miraculous) has the latex used empirically
as anti-cancerous and anti-inflammatory. For there being toxic species in this family and aiming
at the safety in the use of vegetable extracts, such study evaluated the pre-clinical toxicity of the
latex and of the ethanolic extract of the leaves (EEL) of S. umbellatum, administrated by oral route,
in Wistar female rats. The study followed OECD’s Guidelines for test of acute toxicity (Guideline
423) and for subacute toxicity (Guideline 407). In the acute toxicity of latex and EEL, behavioral
and physiological alterations were not observed neither animal’s death in the dose level of 2,000
mg/kg. However, the latex caused congestion and leukocytes infiltration of the kidneys, liver and
lungs, effects not observed with EEL. In the subacute toxicity, dose levels of 50, 100 and 200
mg/kg of EEL did not produced significant dose-dependent alterations in the lab results and no
physiologic, macroscopic and hystopathological alterations. EEL of S. umbellatum is practically
poisonless in acute exposure; already the latex can cause hystological damages. The chronic use of
S. umbellatum needs more specific studies.
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Palavras-chave
Synadenium umbellatum, Toxicidade pré-clinica, Toxicidade aguda, Toxicidade subaguda, Synadenium umbellatum, Pre-clinical toxicity, Acute toxicity, Subacute toxicity
Citação
CUNHA, Luiz C.; AZEREDO, Flaubertt S.; MENDONCA, Ana C. V.; VIEIRA, Marcelo S.; PUCCI, Liuba L.; VALADARES, Marize C.; FREITAS, Helemi O. G.; SENA, Ângela A. S.; LINO JUNIOR, Ruy de Souza. Avaliação da toxicidade aguda e subaguda, em ratos, do extrato etanólico das folhas e do látex de Synadenium umbellatum Pax. Revista Brasileira de Farmacognosia, João Pessoa, v. 19, n. 2A, p. 403-411, abr./jun. 2009.