Evaluation of antinociceptive and antiinfl ammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae)
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Data
2008-09
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Resumo
Croton pullei var. glabrior Lanj. (Euphorbiaceae) is a liana, vastly distributed in the
Amazonian Forest. In the folk medicine, several plants of the Croton genus have been used with
therapeutic purposes in pathologies that involve painful and infl ammatory diseases which justify
this work. The aim of this study was to investigate the antinociceptive and antiinfl ammatory
activities of the C. pullei leaves methanol extract (MECP). MECP reduced in a dose-dependent
manner the number of acetic acid-induced abdominal writhing (1.2%) in mice, suggesting an
antinociceptive activity of the plant. On the other hand, MECP did not signifi cantly modify
the reactivity to the thermal stimulation in the hot-plate test and the reactivity to the chemical
stimulation in the formalin test fi rst phase, indicating a non-opioid mechanism. MECP reduced
the formalin-induced nociception in the second phase, inhibited the croton oil-induced ear edema
and reduced the leukocytes migration in the test of the carrageenan-induced peritonitis, indicating
an antiinfl ammatory activity. Although the mechanisms that underlie these plant effects are not
completely elucidated, these results appear to support the potential medicinal use of Croton
pullei var. glabrior Lanj. against painful and infl ammatory diseases.
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Antiinflamatório, Antinociceptivo, Croton pullei var. glabrior, Fitomedicina, Antiinfl ammatory, Phytomedicine, Antinociceptive, Croton pullei var. glabrior
Citação
ROCHA, Fábio F. et al. Evaluation of antinociceptive and antiinflammatory effects of Croton pullei var. glabrior Lanj. (Euphorbiaceae). Revista Brasileira de Farmacognosia, João Pessoa, v. 18, p. 344-349, July/ Sept. 2008.