Analysis of spleen cells in susceptible and resistant mice with experimental lagochilascariosis
Carregando...
Data
2013
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Lagochilascariosis is an emerging parasitic disease caused by the helminth Lagochilascaris minor. e experimental mouse model
has been used to study the immune response against L. minor infection. In the present work, immunohistochemistry analysis of
spleen cells populations was evaluated in susceptible (C57BL/6) and resistant (BALB/c) mice experimentally infected with L. minor.
e BALB/c mice exhibited increased spleen cell indexes as follows: F4/80+ at 100 days aer infection (DPI), CD4+ at 100 and 250
DPI, CD8+ at 35 and 100 DPI, and CD19+ at 100, 150, and 250 DPI. In the spleens of the infected C57BL/6 mice, increased indexes
of the following spleen cells were observed: F4/80+ cells at 250 DPI, CD4+ cells at 150 DPI, CD8+ cells at 35, 150, and 250 DPI,
and CD19+ cells at 150 to 250 DPI. e index of spleen cells con�rmed the differences between the control and infected groups at
several time points following the infection. ese data demonstrate an association between a preferential increase in the number of
CD4+ and CD19+ spleen cells and resistance to experimental lagochilascariosis in BALB/c mice and between a preferential increase
in the number of CD8+ spleen cells and susceptibility in C57BL/6 mice.
Descrição
Palavras-chave
Citação
LARA, Priscila Guirão; PRUDENTE, Mariana Felix de Souza; DIAS, Neusa Mariana Costa; TAMBOURGI, Denise Vilarinho; LINO-JUNIOR, Ruy de Souza; SPADAFORA-FERREIRA, Mônica; CARVALHAES, Mara Silvia. Analysis of spleen cells in susceptible and resistant mice with experimental lagochilascariosis. ISRN Parasitology, London, v. 2013, p. 1-8, 2013.