Paper spray tandem mass spectrometry based on molecularly imprinted polymer substrate for cocaine analysis in oral fluid

Tavares, Ludmyla Santos; Carvalho, Thays Colletes de; Romão, Wanderson; Vaz, Boniek Gontijo; Chaves, Andréa Rodrigues

Paper spray tandem mass spectrometry based on molecularly imprinted polymer substrate for cocaine analysis in oral fluid

Data

2018

Autores

Tavares, Ludmyla Santos

Carvalho, Thays Colletes de

Romão, Wanderson

Vaz, Boniek Gontijo

Chaves, Andréa Rodrigues

Resumo

This study proposes a new direct and fast method of analysis employing paper spray mass spectrometry (PS-MS). The paper used in the proposed method was modified with molecularly imprinted polymers (MIP) to create a specific site for cocaine analysis in oral fluid. MIP membrane was successfully synthetized and employed. The developed method showed to be linear in a concentration range from LOQ to 100 ng mL–1. The experimental value of LOQ obtained was 1 ng mL–1. The inter-day and intra-day precision and accuracy of the PS-MS method presented values lower than 15%. The total recoveries were also evaluated. The PS-MS method for the analysis of cocaine in oral fluid showed to be very promising and the validation parameters showed a good correlation with the literature.

Palavras-chave

Cocaine, Oral fluid, Analytical validation, Paper spray ionization

Citação

TAVARES, Ludmyla S. et al. Paper spray tandem mass spectrometry based on molecularly imprinted polymer substrate for cocaine analysis in oral fluid. Journal of the American Society for Mass Spectrometry, Washington, v. 29, n. 3, p. 566-572, 2018. DOI: 10.1007/s13361-017-1853-2. Disponível em: https://pubs.acs.org/doi/pdf/10.1007/s13361-017-1853-2. Acesso em: 28 jun. 2023.