Verapamil COER-24 180/240mg na hipertensão arterial leve a moderada em dose única diária avaliado pela monitorização ambulatorial da pressão arterial
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Data
2000
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Resumo
Objective - To evaluate the anti-hypertensive effecft of
verapamil COER-24 180/240 mg in a single dose at bedtime
as single therapy in mild to moderate hypertensives.
Methods – A multicentric, open, placebo controlled
study of 81 hypertensive patients older than 20 years-old
followed to 8 weeks. Blood pressure was measured in
doctor’s office and by 24h ambulatory monitoring (ABPM).
Results – We observed a decreased in systolic and
diastolic blood pressure in doctor’s office at 4 th and 8 th
weeks. ABPM showed that both systolic, diastolic and
mean blood pressure, heart rate and the mean 24-hour
blood pressure load decreased after the 8-week treatment.
In addition, there was a reduction of the double-product,
especially in the morning and 68% of the patients didn’t
have any adverse events.
Conclusion - The theraphy verapamil COER-24 180/
240mg in a single dose is useful for mild and moderate
hypertensive patients, with significant pressure decrease
in both office blood pressure measurements and in the
ABPM/24 hours, as well as showing good tolerability.
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Verapamil, MAPA, Hipertensão arterial, Verapamil, Hypertension, ABPM
Citação
ORTEGA, Katia Coelho et al. Verapamil COER-24 180/240mg na hipertensão arterial leve a moderada em dose única diária avaliado pela monitorização ambulatorial da pressão arterial. Arquivos Brasileiros de Cardiologia, São Paulo, v. 74, n. 3, p. 283-290, 2000.