Effects of Brachiaria brizantha hay containing a steroidal saponin in lambs
| dc.creator | Lima, Flávia Gontijo de | |
| dc.creator | Ribeiro, Carolina Santos | |
| dc.creator | Andrade, Diogo Francescantônio | |
| dc.creator | Costa, Gustavo Lage | |
| dc.creator | Pires, Hugo Cardoso Martins | |
| dc.creator | Guimarães, Victor Yunes | |
| dc.creator | Haraguchi, Mitsue | |
| dc.creator | Fioravanti, Maria Clorinda Soares | |
| dc.date.accessioned | 2018-02-08T10:57:00Z | |
| dc.date.available | 2018-02-08T10:57:00Z | |
| dc.date.issued | 2012 | |
| dc.description.resumo | Several species of Brachiaria are important forages in tropical regions of Brazil and elsewhere worldwide. Some species of Brachiaria have been reported to cause hepatogenous photosensitization in ruminants. Initially, the disease was attributed to Pithomyces chartarum fungus, but recent studies suggest that the steroidal saponins present in the grasses have toxic principles responsible for the photosensitization. The objective of this study was to evaluate hepatic function and the performance of lambs fed with B. brizantha hay or sugar cane (Saccharum officinarum L.), using clinical examinations, laboratory tests, and macro and microscopic analysis of the liver. Twelve Saint Ines lambs were used. The animals were divided into two experimental groups: group hay (six lambs fed with B. brizantha hay, plus a concentrate feed) and group sugar cane (six lambs fed with roughage from sugar cane with added concentrate feed). The hay and sugar cane used to feed the lambs did not contain Pithomyces chartarum spores. The B. brizantha hay contained 0.86% protodioscin, and the animals received a daily protodioscin dose of 200 mg/kg BW. The clinical examination occurred every 7 days, the laboratory tests were done every 14 days, and the animals were weighed every 21 days. At the end of 93 days of feeding, the lambs were slaughtered, the macroscopic analysis of the organs was carried out, and the liver fragments were collected for histological analysis. The lambs were clinically healthy during the whole period, except at the beginning of the experiment when some animals had pneumonia. The only biochemistry alteration suggestive of hepatic damage was an increase (P < 0.05) of the GGT values in both groups. No animal fed with B. brizantha hay showed any macroscopic alterations in the liver. Histological analysis of the liver revealed preserved hepatocytes and the presence of light multifocal infiltration of mononuclear inflammatory cells in the hepatic parenchyma and also in the portal space, indicating mild cholangitis in both groups. Degeneration changes suggestive of hepatic steatosis were observed in four animals fed with sugar cane. Feeding lambs with B. brizantha hay promoted similar performance as feeding animals with sugar cane. We conclude that feeding B. brizantha hay containing the concentration of steroidal saponins used in this study to lambs does not cause toxicity. | pt_BR |
| dc.identifier.citation | LIMA, Flávia G.; RIBEIRO, Carolina S.; ANDRADE, Diogo F.; COSTA, Gustavo L.; PIRES, Hugo C. M.; GUIMARÃES, Victor Y.;HARAGUCHI, Mitsue; FIORAVANTI, Maria Clorinda S. Effects of Brachiaria brizantha hay containing a steroidal saponin in lambs. International Journal of Poisonous Plant Research, Washington, v. 2, n. 1, p. 20-26, 2012. | pt_BR |
| dc.identifier.issn | e- 2154-3216 | |
| dc.identifier.uri | http://repositorio.bc.ufg.br/handle/ri/13590 | |
| dc.language.iso | eng | pt_BR |
| dc.publisher.country | Estados unidos | pt_BR |
| dc.publisher.department | Escola de Veterinária e Zootecnia - EVZ (RG) | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Brachiaria brizantha | pt_BR |
| dc.subject | Cholangitis | pt_BR |
| dc.subject | Gamma glutamyltransferase | pt_BR |
| dc.subject | GGT | pt_BR |
| dc.subject | Hepatogenous photosensitization | pt_BR |
| dc.subject | Protodioscin | pt_BR |
| dc.subject | Saponin | pt_BR |
| dc.title | Effects of Brachiaria brizantha hay containing a steroidal saponin in lambs | pt_BR |
| dc.type | Artigo | pt_BR |