Estudo imunohistoquímico do cerebelo de ratos wistar submetidos à exposição aguda ao etanol no 12º dia de vida intrauterina

Resumo

The effects of the chronic use of ethanol during pregnancy on the morphology and function of the neural system are known in literature, but the effects of the acute use of ethanol at critical moments of pregnancy still need to be clarified. The chronic prenatal exposure to ethanol have been associated to several anomalies in fetus and new-born rats, as alterations in the neuronal density of the piriform cells of the cerebellum, as known as Purkinje cells. In this paper, we have studied the effects of the acute exposure to ethanol at the 12th day of pregnancy of Wistar female rats on the morphology of the cerebellum in the brood. There was no decrease in the granular precursors and Purkinje cells, as occurred in the fetal alcoholic syndrome produced by the chronic exposure of pregnant rats to ethanol, which could be explained by the fact that the ethanol exposure happened after borning of the Purkinje cells, which constituted an adequate media to migration and surviving of the granular cells. The ethanol’s acute effects in begin of the cerebral cortical construction, demonstrate high severity on this tissue, but no in this date, can’t be observed, in this work, the same deleterious effects seen on cerebral cortex in cerebelar cortex.

Descrição

Palavras-chave

Toxicidade aguda, Cerebelo, Etanol, Síndrome alcoólica fetal, Neurônio, Acute toxicity, Cerebellum, Ethanol, Fetal alcoholic syndrome, Neuron

Citação

SOUZA, Aline Gomes; RODRIGUES, Humberto Gabriel; VIEIRA, Clarissa Maria Serpa; MATEUS, Marcus V. C.; AVERSI-FERREIRA, Tales Alexandre. Estudo imunohistoquímico do cerebelo de ratos wistar submetidos à exposição aguda ao etanol no 12º dia de vida intrauterina. Revista Eletrônica de Farmácia, Goiânia, v. 3, n. 1, p. 6-14, jan./jun. 2006. Disponível em: <https://www.revistas.ufg.br/REF/article/view/2068/2011>.