Cashew gum polysaccharide nanoparticles grafted with polypropylene glycol as carriers for diclofenac sodium
Nenhuma Miniatura disponível
Data
2021-04-22
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using
a central composite rotatable design (CCRD). It was demonstrated that the best formulation was
achieved when 10 mg of CGP was mixed with 10 µL of PPG and homogenized at 22,000 rpm for
15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as
increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles
showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of −5.98 mV. The kinetic studies evidenced that
diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h.
These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release
of drugs with similar structures to diclofenac sodium.
Descrição
Palavras-chave
CGP, Polymeric nanoparticles, Release, Drug delivery, Encapsulation, NSAID
Citação
SILVA, Cassio Nazareno Silva da et al. Cashew gum polysaccharide nanoparticles grafted with polypropylene glycol as carriers for diclofenac sodium. Materials, Basel, v. 14, n. 9, e2115, 2021. DOI: 10.3390/ma14092115. Disponível em: https://www.mdpi.com/1996-1944/14/9/2115. Acesso em: 12 fev. 2024.