Tapirira guianensis Aubl. extracts inhibit proliferation and migration of oral cancer cells lines

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dc.creatorOliveira, Renato José Silva
dc.creatorLopes, Gabriela Francine Martins
dc.creatorCamargos, Luiz Fernando de
dc.creatorRibeiro, Ana Maciel
dc.creatorSantos, Fábio Vieira dos
dc.creatorSeverino, Richele Priscila
dc.creatorSeverino, Vanessa Gisele Pasqualotto
dc.creatorTerezan, Ana Paula
dc.creatorThomé, Ralph Gruppi
dc.creatorSantos, Hélio Batista dos
dc.date.accessioned2024-11-11T17:18:12Z
dc.date.available2024-11-11T17:18:12Z
dc.date.issued2016-11
dc.description.abstractCancer of the head and neck is a group of upper aerodigestive tract neoplasms in which aggressive treatments may cause harmful side effects to the patient. In the last decade, investigations on natural compounds have been particularly successful in the field of anticancer drug research. Our aim is to evaluate the antitumor effect of Tapirira guianensis Aubl. extracts on a panel of head and neck squamous cell carcinoma (HNSCC) cell lines. Analysis of secondary metabolites classes in fractions of T. guianensis was performed using Nuclear Magnetic Resonance (NMR). Mutagenicity effect was evaluated by Ames mutagenicity assay. The cytotoxic effect, and migration and invasion inhibition were measured. Additionally, the expression level of apoptosis-related molecules (PARP, Caspases 3, and Fas) and MMP-2 was detected using Western blot. Heterogeneous cytotoxicity response was observed for all fractions, which showed migration inhibition, reduced matrix degradation, and decreased cell invasion ability. Expression levels of MMP-2 decreased in all fractions, and particularly in the hexane fraction. Furthermore, overexpression of FAS and caspase-3, and increase of cleaved PARP indicates possible apoptosis extrinsic pathway activation. Antiproliferative activity of T. guianensis extract in HNSCC cells lines suggests the possibility of developing an anticancer agent or an additive with synergic activities associated with conventional anticancer therapy.
dc.identifier.citationOLIVEIRA, Renato José Silva et al. Tapirira guianensis Aubl. extracts inhibit proliferation and migration of oral cancer cells lines. International Journal of Molecular Sciences, Basel, v. 17, n. 11, e1839, 2016. DOI: 10.3390/ijms17111839. Disponível em: https://www.mdpi.com/1422-0067/17/11/1839. Acesso em: 14 ago. 2024.
dc.identifier.doi10.3390/ijms17111839
dc.identifier.issne- 1422-0067
dc.identifier.urihttp://repositorio.bc.ufg.br//handle/ri/25872
dc.language.isoeng
dc.publisher.countrySuica
dc.publisher.departmentInstituto de Química - IQ (RMG)
dc.rightsAcesso Aberto
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHNSCC
dc.subjectCytotoxic activity
dc.subjectAlkaloids
dc.subjectApoptosis markers
dc.titleTapirira guianensis Aubl. extracts inhibit proliferation and migration of oral cancer cells lines
dc.typeArtigo

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