Synadenium umbellatum: citotoxicidade e danos ao DNA de células da medula óssea de camundongos
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Data
2007
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Resumo
In the present study we investigated, in vitro and in vivo,
the cytotoxic and mutagenic potential of the Synadenium
umbellatum ethanolic extract (SUEE) on the bone marrow cells of mice. In vitro cytotoxicity was assayed incubating
bone marrow cells with different concentrations (40-0.312
mg/mL) of SUEE for 12, 24 or 48 h using the MTT
tetrazolium reduction test and the trypan blue exclusion
test. The micronuclei assay was performed to determine
mutagenic effects of mice orally exposed to different doses
of SUEE (10, 25 or 50 mg/kg/day) in 24 h. Our results
demonstrated that SUEE has, in a dose-dependent
manner, potential cytotoxic and mutagenic effects on the
bone marrow cells of mice. Further studies are needed to
expand the knowledge of the toxicological/
pharmacological potential of the SUEE.
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Palavras-chave
Synadenium umbellatum, DNA/danos, Citotoxidade, estudo experimental, Micronúcleo, Medula óssea, Synadenium umbellatum, DNA/ damage, Cytotoxicity, Micronuclei, Bone marrow, Experimental study
Citação
VALADARES, Marize Campos; CASTRO, Núbia Cristiana de; CUNHA, Luiz Carlos da. Synadenium umbellatum: citotoxicidade e danos ao DNA de células damedula óssea de camundongos. Revista Brasileira de Ciências Farmacêuticas, São Paulo, v. 43, n. 4, p. 631-638, 2007.