New surgery technique for refractory macular hole guided by intraoperative OCT: free internal limiting membrane flap and autologous blood clot
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Bastos, Thaís Marino de Azeredo
Neves, Laís Lauria
Freitas, Letícia Pinheiro de
Isaac, David Leonardo Cruvinel
Casella, Antonio Marcelo Barbante
Ávila, Marcos Pereira de
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Background Present a new surgical technique which involves using pars plana vitrectomy (PPV) combined
with a free internal limiting membrane (ILM) flap anchored by an intraoperatively obtained blood clot, assisted
by intraoperative optical coherence tomography (i-OCT).
Methods This is a prospective interventional non-comparative study with three cases of recurrent or refractory
macular hole treated with a new surgical technique using autologous blood clot obtained from the retinal vessels.
Results This study included 3 eyes of 3 patients. All patients were previously treated with a PPV and internal limiting
membrane peeling. One week post-operatively, all operated eyes showed closure of the macular hole. No complica
tions secondary to the surgical technique occurred.
Conclusion This is a small case series that obtained anatomical success in the macular hole closure with a reproduc
ible technique involving the use of i-OCT to position a free ILM flap, anchored by a blood clot obtained from per oper
atory retinal bleeding. Further controlled research needs to be done to prove the efficacy.
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BASTOS, Thais Marino de Azeredo et al. New surgery technique for refractory macular hole guided by intraoperative OCT: free internal limiting membrane flap and autologous blood clot. International Journal of Retina and Vitreous, Berlin, v. 11, e60, 2025. DOI: 10.1186/s40942-025-00681-6. Disponível em: https://link.springer.com/article/10.1186/s40942-025-00681-6. Acesso em: 22 abr. 2026.