A comparison between diuretics and angiotensin- receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial

Página do item simplificado
dc.creatorFuchs, Flávio Danni
dc.creatorFuchs, Sandra Cristina Pereira Costa
dc.creatorMoreira, Leila Beltrami
dc.creatorGus, Miguel
dc.creatorNóbrega, Antonio Claudio Lucas da
dc.creatorFigueiredo, Carlos Eduardo Poli de
dc.creatorMion Junior, Decio
dc.creatorBortolotto, Luiz Aparecido
dc.creatorConsolim-Colombo, Fernanda Marciano
dc.creatorNobre, Fernando
dc.creatorCoelho, Eduardo Barbosa
dc.creatorMartin, Jose Fernando Vilela
dc.creatorMoreno Junior, Heitor
dc.creatorCesarino, Evandro José
dc.creatorFranco, Roberto Jorge da Silva
dc.creatorBrandão, Andréa Araujo
dc.creatorSousa, Marcos Roberto de
dc.creatorRibeiro, Antônio Luiz Pinho
dc.creatorJardim, Paulo Cesar Brandao Veiga
dc.creatorAfiune Neto, Abrahão
dc.creatorScala, Luíz Cesar Nazário
dc.creatorGomes, Marco Antônio Mota
dc.creatorChaves Júnior, Hilton de Castro
dc.creatorAlves, João Guilherme Bezerra
dc.creatorSobral Filho, Dário Celestino
dc.creatorSilva, Ricardo Pereira e
dc.creatorFigueiredo Neto, José Albuquerque de
dc.creatorIrigoyen, Maria Claudia Costa
dc.creatorCastro, Iran
dc.creatorSteffens, André Avelino
dc.creatorSchlatter, Rosane Paixão
dc.creatorMello, Renato Gorga Bandeira de
dc.creatorMosele, Francisca
dc.creatorGhizzoni, Flávia
dc.creatorBerwanger, Otávio
dc.date.accessioned2019-09-18T13:06:01Z
dc.date.available2019-09-18T13:06:01Z
dc.date.issued2011
dc.description.abstractBackground: Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics are as efficacious as other agents, are well tolerated, have longer duration of action and low cost, but have been scarcely compared with ARBs. A study comparing diuretic and ARB is therefore warranted. Methods/design: This is a randomized, double-blind, clinical trial, comparing the association of chlorthalidone and amiloride with losartan as first drug option in patients aged 30 to 70 years, with stage I hypertension. The primary outcomes will be variation of blood pressure by time, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new subclinical atherosclerosis and sudden death. The study will last 18 months. The sample size will be of 1200 participants for group in order to confer enough power to test for all primary outcomes. The project was approved by the Ethics committee of each participating institution. Discussion: The putative pleiotropic effects of ARB agents, particularly renal protection, have been disputed, and they have been scarcely compared with diuretics in large clinical trials, despite that they have been at least as efficacious as newer agents in managing hypertension. Even if the null hypothesis is not rejected, the information will be useful for health care policy to treat hypertension in Brazil.pt_BR
dc.identifier.citationFUCHS, Flavio D. et al. A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial. Trials, London, v. 12, n. 53, p. 1-5, 2011.pt_BR
dc.identifier.doi10.1186/1745-6215-12-53
dc.identifier.issne- 1745-6215
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18137
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Medicina - FM (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleA comparison between diuretics and angiotensin- receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trialpt_BR
dc.typeArtigopt_BR

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Artigo - Flávio Danni Fuchs - 2011.pdf
Tamanho:
387.64 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar

Coleções

FM - Artigos publicados em periódicos