Biodistribution profile of magnetic nanoparticles in cirrhosis-associated hepatocarcinogenesis in rats by AC biosusceptometry
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2022
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Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose
and treat liver diseases in recent years, this study aimed to assess how the condition of
cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a realtime
image acquisition approach, the distribution profile of MNPs after intravenous administration
was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile
based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver
position according to the anatomical references previously selected. The signals obtained allowed
for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is
compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows
its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic
stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal
circulation was considered the potential reason for the change in the distribution of MNPs.
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AC biosuceptometry, Nanotechnology, Magnetic nanoparticles, Cirrhosis-associated rat hepatocarcinogenesis
Citação
SOARES, Guilherme A. et al. Biodistribution profile of magnetic nanoparticles in cirrhosis-associated hepatocarcinogenesis in rats by AC biosusceptometry. Pharmaceutics, Basel, v. 14, n. 9, e1907, 2022. DOI: 10.3390/pharmaceutics14091907. Disponível em: https://www-ncbi-nlm-nih.ez49.periodicos.capes.gov.br/pmc/articles/PMC9504370/pdf/pharmaceutics-14-01907.pdf. Acesso em: 11 abr. 2023.