Toxicity of silver nanoparticles released by Hancornia speciosa (Mangabeira) biomembrane

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dc.creatorAlmeida, Luciane Madureira de
dc.creatorMagno, Lais Nogueira
dc.creatorPereira, Aryelle Canedo
dc.creatorGuidelli, Éder José
dc.creatorBaffa Filho, Oswaldo
dc.creatorKinoshita, Angela Mitie Otta
dc.creatorGonçalves, Pablo José
dc.date.accessioned2024-07-08T12:18:49Z
dc.date.available2024-07-08T12:18:49Z
dc.date.issued2019
dc.description.abstractRecent research has shown that latex from different species is able to produce tissue replacement and regeneration. Particularly, biomembranes obtained from Hancornia speciosa latex (HSB) have shown high angiogenic and osteogenic activity. Considering new materials for wound healing, it would be interesting to develop a product combining antibacterial and antifungal activities. Silver nanoparticles (AgNP) have been commonly used for this purpose in medicinal products and devices for decades. In order to combine angiogenic, antibacterial and antifungal properties on the same platform, we developed an HSB containing 3 concentrations of AgNP. It was observed that the HSB successfully accommodated the AgNP in the matrix and released them in a controlled way. The release dynamics of AgNP by HSB was described by UV–vis absorption spectroscopy. The released nanoparticles were evaluated by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS) measurements. In addition, the cytotoxic and genotoxic effects were evaluated using the Allium cepa assay. The results showed no cytotoxic effect of HSB-AgNP in all studied concentrations. The genotoxic effect was observed in HSB-AgNP at the two highest concentrations, however not at the lowest concentration. Thus, the addition of AgNP at the lowest concentration can improve the pharmacological activity of HSB without causing a toxic effect on vegetal cells. Therefore, the H. speciosa latex biomembrane presented in this paper combines angiogenic, anti-inflammatory and antibacterial properties and can be considered potentially new biomaterial for wound-healing.
dc.identifier.citationALMEIDA, Luciane M. et al. Toxicity of silver nanoparticles released by Hancornia speciosa (Mangabeira) biomembrane. Spectrochimica Acta Part A: molecular and biomolecular spectroscopy, Amsterdam, v. 210, p. 329-334, 2019. DOI: 10.1016/j.saa.2018.11.050. Disponível em: https://www.sciencedirect.com/science/article/pii/S1386142518310473. Acesso em: 3 jul. 2024.
dc.identifier.doi10.1016/j.saa.2018.11.050
dc.identifier.issn1386-1425
dc.identifier.issne- 1873-3557
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1386142518310473
dc.language.isoeng
dc.publisher.countryHolanda
dc.publisher.departmentInstituto de Física - IF (RMG)
dc.rightsAcesso Restrito
dc.subjectHancornia speciosa latex
dc.subjectBiomaterial
dc.subjectBiomembrane
dc.subjectAngiogenic activity
dc.subjectNanoparticles
dc.subjectAntibacterial properties
dc.subjectAllium cepa model
dc.titleToxicity of silver nanoparticles released by Hancornia speciosa (Mangabeira) biomembrane
dc.typeArtigo

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